DIET, MAMMOGRAPHIC FEATURES OF BREAST-TISSUE, AND BREAST-CANCER RISK
DIET, MAMMOGRAPHIC FEATURES OF BREAST-TISSUE, AND BREAST-CANCER RISK
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DOI：
10.1093/oxfordjournals.aje.a115305
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发表时间：
1989-07-01
影响因子：
5
通讯作者：
MEYER, F
中科院分区：
文献类型：
--
作者：
BRISSON, J;VERREAULT, R;MEYER, F
这项病例对照研究旨在重新评估乳腺X线照片上乳腺组织形态与乳腺癌风险的相关性，并评估饮食，特别是脂肪和维生素A的摄入与高风险乳腺X线照片的关系。这些病例包括1982-1984年在魁北克首次接受治疗的290例新诊断的乳腺癌患者。对照组包括645名参加加拿大全国乳腺筛查研究的妇女。P2或DY型乳腺癌的风险高于N1型乳腺癌的风险（相对风险（RR）= 3.7，95%可信区间（CI）2.0-7.0）。此外，风险随着乳房X线片上结节和均匀密度的程度而规律性地增加。与无结节性或均匀密度的女性相比，60%或以上乳腺体积显示结节性或均匀密度的女性的相对风险为5.5（95%CI 2.3-13.2）。在对照组中，能量调整饱和脂肪摄入量的增加与高风险乳房X线摄影特征的程度增加相关。然而，能量调节的多不饱和脂肪或胆固醇摄入似乎并没有影响乳房X线照片上看到的乳房组织形态。增加类胡萝卜素和纤维摄入量与乳腺X线照片上密度的程度降低有关，但视黄醇摄入量似乎对乳腺X线照片特征几乎没有影响。这些数据表明，饱和脂肪摄入量的增加以及类胡萝卜素和纤维摄入量的减少可能通过这些营养素对乳腺组织形态的影响而与乳腺癌风险的增加有关。
This case-control study was designed to reevaluate the association of the morphology of breast tissue seen on mammograms with breast cancer risk and to assess the relation of diet, especially intake of fat and vitamin A, to the high-risk mammographic images. The cases included 290 patients with newly diagnosed breast cancer who were first treated in Quebec in 1982-1984. The controls included 645 women who participated in the Canadian National Breast Screening Study. Risk of breast cancer was higher among women with the P2 or DY parencymal pattern (relative risk (RR) = 3.7, 95% confidence interval (Cl) 2.0-7.0) than it was among those with the N1 pattern. Moreover, risk increased regularly with the extent of nodular and homogeneous densities on the mammogram. Relative risk was 5.5 (95% Cl 2.3-13.2) for women in whom 60% or more of the volume of the breast showed either nodular or homogeneous densities compared with women without such densities. Among controls, increase in energy-adjusted saturated fat intake was associated with an increase in extent of high-risk mammographic features. Energy-adjusted polyunsaturated fat or cholesterol intake did not, however, appear to influence the morphology of breast tissue seen on the mammogram. Increasing carotenoid and fiber intakes were associated with a reduction of the extent of densities on the mammogram, but retinol intake seemed to have little or no effect on mammographic features. These data suggest that elevation in saturated fat intake and reduction in carotenoid and fiber intakes may be related to an increase in breast cancer risk through effects of these nutrients on breast tissue morphology.