Are gonadal steroid hormones involved in disorders of brain aging?
Are gonadal steroid hormones involved in disorders of brain aging?
复制标题
性腺类固醇激素是否与大脑衰老疾病有关？
DOI：
10.1046/j.1474-9728.2003.00013.x
复制
发表时间：
2003
期刊：
影响因子：
7.8
通讯作者：
Garcia-Segura,LuisM
中科院分区：
文献类型：
--
作者：
Azcoitia,Iñigo;DonCarlos,LydiaL;Garcia-Segura,LuisM
人类衰老与循环性腺类固醇激素的减少有关。由于这些激素充当神经元和神经胶质细胞的营养因子，因此性类固醇水平的下降可能会导致老年神经退行性疾病的风险增加。性类固醇在几种中枢和外周神经退行性疾病动物模型中具有神经保护作用，临床数据表明这些激素可以降低老年人患神经病理学的风险。为了解老年动物神经系统中性类固醇的作用机制而进行的研究可能会出现治疗老年相关神经疾病的潜在治疗方法。老年大脑合成和代谢性类固醇内源能力的改变，以及神经系统中性类固醇受体信号传导可能与年龄相关的改变，是未来研究的重要领域。
Human aging is associated with a decrease of circulating gonadal steroid hormones. Since these hormones act as trophic factors for neurones and glia, it is possible that the decrease in sex steroid levels may contribute to the increased risk of neurodegenerative disorders with advanced age. Sex steroids are neuroprotective in several animal models of central and peripheral neurodegenerative diseases, and clinical data suggest that these hormones may reduce the risk of neural pathology in aged humans. Potential therapeutic approaches for aged‐associated neural disorders may emerge from studies conducted to understand the mechanisms of action of sex steroids in the nervous system of aged animals. Alterations in the endogenous capacity of the aged brain to synthesize and metabolize sex steroids, as well as possible aged‐associated modifications in the signalling of sex steroid receptors in the nervous system, are important areas for future investigation.