Effects of daily and acute restraint stress during lactation on maternal aggression and behavior in mice
Effects of daily and acute restraint stress during lactation on maternal aggression and behavior in mice
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DOI：
10.1080/10253890600969106
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发表时间：
2006-09-01
影响因子：
2.3
通讯作者：
Stevenson, Sharon A.
中科院分区：
文献类型：
--
作者：
Gammie, Stephen C.;Stevenson, Sharon A.
哺乳期对压力源的反应性降低可能会通过最大限度地减少压力对产妇护理的影响来提高产妇护理（包括对后代的防御）的表达。虽然在怀孕期间施加的压力对母亲的侵略（或后代的防御）有不同的影响，到目前为止，没有研究已经检查了产后期间施加的压力对母亲的侵略的影响。在这项研究中，我们研究了每日和急性约束压力（30分钟）施加产后母亲的攻击和其他母亲的行为的影响。日常约束（测试前2小时结束）并没有改变任何措施的母亲的行为，包括护理，舔和梳理的幼崽和幼崽检索，或任何措施的母亲的侵略。与此相反，急性应激显着损害的总时间侵略性和攻击次数，但小狗检索是正常的。c-Fos水平在与急性应激相关的许多脑区显著升高，包括外侧隔（LS）、尾侧导水管周围灰质和内侧杏仁核（MeA），这表明应激反应可能改变攻击性的部位。总之，结果表明，急性约束压力损害产妇的侵略，并提供了一个起点，为未来的研究如何压力反应途径可能与产妇侵略途径交叉。
A decreased reactivity to stressors during lactation might heighten the expression of maternal care ( including defense of offspring) by minimizing the extent to which stress can impact maternal care. Although stressors applied during pregnancy have variable effects on maternal aggression ( or defense of offspring), to date no study has examined the effects of stress applied during the postpartum period on maternal aggression. In this study, we examined the effects of both daily and acute restraint stress ( 30 min) applied postpartum on maternal aggression and other maternal behaviors. Daily restraint ( ending 2 h before testing) did not alter any measure of maternal behavior, including nursing, licking and grooming of pups and pup retrieval, or any measure of maternal aggression. In contrast, acute stress significantly impaired total time aggressive and number of attacks, but pup retrieval was normal. c- Fos levels were significantly elevated in a number of brain regions in association with acute stress, including lateral septum ( LS), caudal periaqueductal gray and medial amygdala ( MeA), suggesting possible sites where stress reactivity could alter aggression. Together, the results indicate that acute restraint stress impairs maternal aggression and provide a starting point for future studies examining how stress reactivity pathways may intersect with maternal aggression pathways.