Copper-catalyzed domino intramolecular cyclization: a facile and efficient approach to polycyclic indole derivatives.
Copper-catalyzed domino intramolecular cyclization: a facile and efficient approach to polycyclic indole derivatives.
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DOI：
10.1039/c1ob06488f
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发表时间：
2012-02
影响因子：
3.2
通讯作者：
Zi‐Hao Xia;Kuo Wang;Jiening Zheng;Zheyong Ma;Zhan-Guo Jiang;Xiaoxia Wang;Xin Lv
中科院分区：
文献类型：
--
作者：
Zi‐Hao Xia;Kuo Wang;Jiening Zheng;Zheyong Ma;Zhan-Guo Jiang;Xiaoxia Wang;Xin Lv
Cu（2）O催化的多米诺分子内C-N偶联/C-Y（Y = O，S，N）键的形成是温和而有效的。因此，恶嗪并[3，2-a]吲哚，噻嗪并[3，2-a]吲哚和吲哚并[2，1-B]喹唑啉衍生物容易地从容易获得的偕-二溴乙烯基体系组装。该方法具有通用性和实用性，即使在空气气氛下也能以良好的产率得到各种吲哚化合物。
A mild and efficient Cu(2)O-catalyzed domino intramolecular C-N coupling/C-Y (Y = O, S, N) bond formation was successfully achieved. Thus oxazino[3,2-a]indole, thiazino[3,2-a]indole and indolo[2,1-b]quinazoline derivatives were facilely assembled from readily accessible gem-dibromovinyl systems. The protocol is general and practical, affording a variety of the indole-incorporated products in good to excellent yields even under air atmosphere.