Asymmetric Synthesis of Cyclopropylmethanamines by Rhodium-catalyzed Cyclopropanation of Pinacol Allylboronate with N-Sulfonyl-1,2,3-triazoles
Asymmetric Synthesis of Cyclopropylmethanamines by Rhodium-catalyzed Cyclopropanation of Pinacol Allylboronate with N-Sulfonyl-1,2,3-triazoles
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DOI：
10.1246/cl.160465
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发表时间：
2016-06
影响因子：
1.6
通讯作者：
T. Miura;Takayuki Nakamuro;Hiroki Nikishima;M. Murakami
中科院分区：
文献类型：
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作者：
T. Miura;Takayuki Nakamuro;Hiroki Nikishima;M. Murakami
在此，报道了铑(II)催化的频那醇烯丙基硼酸酯与N-磺酰基-1,2,3-三唑的环丙烷化反应。硼基取代的环丙基甲胺以高度非对映选择性和对映选择性方式生产。各种含有季立构中心的环丙基甲胺均由它们衍生。
Herein, the rhodium(II)-catalyzed cyclopropanation reaction of pinacol allylboronate with N-sulfonyl-1,2,3-triazoles is reported. Boryl-substituted cyclopropylmethanamines are produced in a highly diastereo- and enantioselective manner. Various cyclopropylmethanamines containing a quaternary stereocenter are derived from them.