Are infrequent episodic, frequent episodic and chronic tension-type headache inherited? A population-based study of 11 199 twin pairs
Are infrequent episodic, frequent episodic and chronic tension-type headache inherited? A population-based study of 11 199 twin pairs
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偶发性头痛、频繁发作性头痛和慢性紧张型头痛是否具有遗传性？
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
Niels Levi
中科院分区：
文献类型：
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作者：
Michael Bjørn Russell;J. Saltyte;Niels Levi
目的是调查遗传和环境因素对罕见发作性、频繁发作性和慢性紧张型头痛的重要性。从基于人口的丹麦双胞胎登记处招募的双胞胎收到了一份张贴的问卷。只有双胞胎都回答的双胞胎才被包括在内。共纳入3523对同卵双生子（MZ）、4150对异卵双生子（DZ）和3526对异卵双生子。频繁发作和慢性紧张型头痛的患病率在女性中明显高于男性，并且在合并偏头痛的患者中明显更高。无或频繁发作性紧张型头痛的MZ双胞胎的一致率显著高于同性别DZ双胞胎，而慢性紧张型头痛的差异不显著。MZ和同性别DZ双胞胎中罕见发作性紧张型头痛的一致率在女性中有显著差异，但在男性中无显著差异，尽管两种性别的差异很小。我们的结论是，遗传因素在没有和频繁发作的紧张型头痛中发挥作用，而罕见的发作性紧张型头痛主要是由环境因素引起的。关于慢性紧张型头痛的数据有限，因此无法得出确切的结论。
The objective was to investigate the importance of genetic and environmental factors for infrequent episodic, frequent episodic and chronic tension-type headache. Twin pairs recruited from the population-based Danish Twin Registry received a posted questionnaire. Only twin pairs where both twins replied were included. A total of 3523 monozygotic (MZ), 4150 dizygotic (DZ) same-gender and 3526 DZ opposite-gender twin pairs were included. The prevalence of frequent episodic and chronic tension-type headache was significantly more frequent in women than men, and significantly higher in those with co-occurrence of migraine. The concordance rates were significantly higher in MZ than same-gender DZ twin pairs with no or frequent episodic tension-type headache, while the difference was not significant in chronic tension-type headache. The concordance rates of infrequent episodic tension-type headache in MZ and same-gender DZ twin pairs was significantly different in women but not in men, although the difference was small in both genders. We conclude that genetic factors play a role in no and frequent episodic tension-type headache, while infrequent episodic tension-type headache is caused primarily by environmental factors. The data regarding chronic tensiontype headache were limited, so no firm conclusion could be drawn.