The effect of micronutrient supplementation on treatment outcome in patients with pulmonary tuberculosis:: a randomized controlled trial in Mwanza, Tanzania
The effect of micronutrient supplementation on treatment outcome in patients with pulmonary tuberculosis:: a randomized controlled trial in Mwanza, Tanzania
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DOI：
10.1111/j.1365-3156.2005.01463.x
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发表时间：
2005-09-01
影响因子：
3.3
通讯作者：
Friis, H
中科院分区：
文献类型：
--
作者：
Range, N;Andersen, ÅB;Friis, H
目的本研究的目的是评估微量营养素补充对结核病（TB）患者培养转化的影响。坦桑尼亚肺结核患者锌和多种微量营养素（MMN）补充剂的双盲安慰剂对照2 × 2试验。经显微镜或培养呈阳性。在第8周，25%的患者为涂片阳性，但只有11%的患者为培养阳性（P < 0.0001）。在第8周时，在分配至MMN或安慰剂组的受试者中未观察到培养物转化率的显著差异（89.5 vs. 86.2%，P = 0.29），尽管在第4周时，分配至MMN组的受试者的培养物转化率略有降低（42.8 vs. 52.8%，P = 0.058）。锌对培养转化率无影响。在第8周，MMN使体重增加0.78 kg [95%置信区间（CI）：0.12-1.43]，而锌补充没有影响。MMN和锌的影响没有相互作用，也没有MMN或锌与人类免疫缺陷病毒的状态，性别和文化intensity.CONCLUSION没有锌或MMN补充文化转换有显着影响，但MMN补充增加体重增加结核病患者。
OBJECTIVE The aim of the study was to assess the effects of micronutrient supplementation on culture conversion in tuberculosis (TB) patients.DESIGN The study was a randomized, double-blind placebo-controlled 2 x 2 trial of zinc and multi-micronutrient (MMN) supplementation in pulmonary TB patients in Tanzania.RESULTS A total of 499 pulmonary TB patients were included in the trial after being confirmed sputum-positive by microscopy or culture. At 8 weeks, 25% were sputum-smear positive but only 11% were culture-positive (P < 0.0001). No significant differences were observed in culture conversion rate among those allocated to MMN or placebo (89.5 vs. 86.2%, P = 0.29) at 8 weeks, although at week 4 those allocated to MMN had a slightly reduced culture conversion rate (42.8 vs. 52.8%, P = 0.058). Zinc had no effects on culture conversion. MMN increased weight gain by 0.78 kg [95% confidence interval (CI): 0.12-1.43] at week 8, while zinc supplementation had no effect. The effects of MMN and zinc did not interact and neither MMN nor zinc interacted with human immunodeficiency virus status, sex and culture-intensity at baseline.CONCLUSION Neither zinc nor MMN supplementation had significant effects on culture conversion, but MMN supplementation increased weight gain in TB patients.