Changes in capsule and drug resistance of Pneumococci after introduction of PCV7, Japan, 2010-2013.
Changes in capsule and drug resistance of Pneumococci after introduction of PCV7, Japan, 2010-2013.
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DOI：
10.3201/eid2007.131485
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发表时间：
2014-07
影响因子：
11.8
通讯作者：
Invasive Pneumococcal Diseases Surveillance Study Group
中科院分区：
文献类型：
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作者：
Chiba N;Morozumi M;Shouji M;Wajima T;Iwata S;Ubukata K;Invasive Pneumococcal Diseases Surveillance Study Group
剧烈的变化威胁到该疫苗的整体有效性。本研究旨在阐明7价肺炎球菌结合疫苗（PCV7）引入日本后，侵袭性肺炎球菌病（IPD）儿童肺炎链球菌分离株中介导β-内酰胺和大环内酯类耐药的血清型和基因型变化；2010年4月至2013年3月期间，341家参与的综合医院开展了IPD监测。2010年、2011年和2012年分别收集了300份、146份和156份肺炎球菌分离株。3年间，传染性分离株中疫苗血清型的比例从73.3%下降到54.8%，再下降到14.7%。在疫苗血清型菌株中，基因型耐青霉素肺炎链球菌菌株也逐年下降。在非疫苗血清型毒株中，19A、15A、15B、15C和24在2012年有所增加。尤其在15A和35B血清型耐青霉素肺炎链球菌的基因型分离株中，以及15A、15B、15C和24株由erm(B)基因介导的大环内酯类药物耐药性中，发现了增加。
Drastic changes threaten overall effectiveness of this vaccine. We aimed to clarify changes in serotypes and genotypes mediating β-lactam and macrolide resistance in Streptococcus pneumoniae isolates from Japanese children who had invasive pneumococcal disease (IPD) after the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into Japan; 341 participating general hospitals conducted IPD surveillance during April 2010–March 2013. A total of 300 pneumococcal isolates were collected in 2010, 146 in 2011, and 156 in 2012. The proportion of vaccine serotypes in infectious isolates decreased from 73.3% to 54.8% to 14.7% during the 3 years. Among vaccine serotype strains, genotypic penicillin-resistant S. pneumoniae strains also declined each year. Among nonvaccine serotype strains, 19A, 15A, 15B, 15C, and 24 increased in 2012. Increases were noted especially in genotypic penicillin-resistant S. pneumoniae isolates of serotypes 15A and 35B, as well as macrolide resistance mediated by the erm(B) gene in 15A, 15B, 15C, and 24.