Wiring cost in the organization of a biological neuronal network
Wiring cost in the organization of a biological neuronal network
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DOI：
10.1016/j.physa.2005.12.013
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发表时间：
2006-07-15
影响因子：
3.3
通讯作者：
Kim, Beom Jun
中科院分区：
文献类型：
--
作者：
Ahn, Yong-Yeol;Jeong, Hawoong;Kim, Beom Jun
为了研究布线成本在秀丽隐杆线虫神经元网络组织中的作用，我们基于神经元的几何位置构建了秀丽隐杆线虫的空间神经元图。我们证明了欧几里得长度d的神经元间连接的数量随着d呈指数衰减，这意味着连接成本（定义为神经元间距离的总和）在实际的神经元网络中起着重要作用。利用边缘交换和顶点交换两种方法对神经网络进行系统洗牌，证明了神经元的位置不是随机分布的，而是有组织的，从而降低了连接成本。此外，我们还讨论了布线成本和网络性能之间的权衡。(c) 2006 Elsevier B.V.版权所有
To find out the role of the wiring cost in the organization of the neuronal network of the nematode Caenorhabditis elegans, we build the spatial neuronal map of C elegans based on geometrical positions of neurons. We show that the number of interneuronal connections of the Euclidean length d decays exponentially with d, implying that the wiring cost, defined as the sum of the interneuronal distances, plays an important role in the actual neuronal network. Using the two methods to shuffle the neuronal network in systematic ways, the edge exchange and the vertex swapping, we show that positions of neurons are not randomly distributed but organized to reduce the wiring cost. Furthermore, we discuss the trade-off between the wiring cost and the performance of the network. (c) 2006 Elsevier B.V. All rights reserved.