IL-1β-511 and IL-1RN*2 polymorphisms in inflammatory bowel disease: An Italian population study and meta-analysis of European studies
IL-1β-511 and IL-1RN*2 polymorphisms in inflammatory bowel disease: An Italian population study and meta-analysis of European studies
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DOI：
10.1016/j.dld.2009.06.016
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发表时间：
2010-03-01
影响因子：
4.5
通讯作者：
Delle Fave, Gianfranco
中科院分区：
文献类型：
--
作者：
Corleto, Vito D.;Pagnini, Cristiano;Delle Fave, Gianfranco
背景资料：一些研究试图找到遗传多态性与炎症性肠病患病率和/或表型之间的可能关联。我们的目的是检测意大利所有人群中炎症性肠病患者和对照组中白细胞介素-1通路的两种多态性（IL-1 β-511和IL-1 RN *2）的频率和表型相关性，并将我们的数据与欧洲先前发表的类似研究进行比较。我们通过基于聚合酶链反应（PCR）的方法筛选了290例炎症性肠病患者（178例溃疡性结肠炎和112例克罗恩病）和106例对照组的IL-1 β-511和IL-1 RN *2多态性。IL-1 β-511和IL-1 RN *2多态性在欧洲炎症性肠病患者中的患病率通过对先前发表的研究进行荟萃分析使用Mantel-Haenszel方法计算。IL-1 β-511突变的克罗恩病患者并发症的发生率较高。IL-1 RN *2突变和炎症性肠病的高风险之间的关联的趋势已被发现，只有在研究与北方欧洲Populations.Conclusions：IL-1 β-511突变可以与复杂的疾病行为在意大利克罗恩病患者。IL-1 RN *2突变可能在北方欧洲炎症性肠病患者中发挥作用。(C)2009 Editrice Gastroenterology Italiana S.r.l.由爱思唯尔有限公司出版。保留所有权利。
Background: Several studies have tried to find possible associations between genetic polymorphisms and inflammatory bowel disease prevalence and/or phenotype. Our objectives were to test the frequency and phenotypic association of two polymorphisms of the interleukin-1 pathway, IL-1 beta-511 and IL-1RN*2, in inflammatory bowel disease patients and controls from all Italian Population, and to compare our data with previously published similar studies in Europe.Methods: We screened 290 inflammatory bowel disease patients (178 ulcerative colitis and 112 Crohn's disease) and 106 controls for IL-1 beta-511 and IL-1RN*2 polymorphisms by polymerase chain reaction (PCR)-based methods. The prevalence of the IL-1 beta-511 and IL-1RN*2 polymorphisms in European inflammatory bowel disease patients Was Calculated by a meta-analysis of previously published studies using the Mantel-Haenszel method.Results: No correlation between the IL-1 polymorphisms and inflammatory bowel disease prevalence was found in our study Population. Crohn's disease patients with the IL-1 beta-511 mutation had a higher rate of complicated disease. A trend for an association between the IL-1RN*2 mutation and a higher risk for inflammatory bowel disease has been found only in Studies with Northern European Populations.Conclusions: The IL-1 beta-511 mutation can be associated with complex disease behaviour in Italian Crohn's disease patients. The IL-1RN*2 Mutation may play a role in Northern European people with inflammatory bowel disease. (C) 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.