Bladder cancer in cancer patients: population-based estimates from a large Swedish study.
Bladder cancer in cancer patients: population-based estimates from a large Swedish study.
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DOI：
10.1038/sj.bjc.6605325
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发表时间：
2009-10-06
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
这项研究量化了癌症患者患膀胱肿瘤的风险，考虑了首次诊断时的年龄、患者的性别和诊断之间的间隔时间。我们使用标准化发病率比（SIR）比较了967767例癌症患者的膀胱肿瘤发病率与瑞典普通人群的发病率。共有3324名男性和1560名女性患者在首次癌症诊断后至少1年发生膀胱肿瘤。膀胱癌和肾盂癌术后，女性膀胱肿瘤的SIRs高于男性。患有肺、胃和喉肿瘤的男性属于膀胱癌高风险人群。乳腺癌、卵巢癌和宫颈癌的治疗似乎有助于膀胱肿瘤的后续发展。睾丸癌、子宫颈癌和子宫内膜癌术后观察到较长的潜伏期（16-25年）。检测偏倚在前列腺癌后有重要作用。化疗与环磷酰胺和顺铂，以及放疗，似乎增加了随后的膀胱肿瘤的风险。这些以人群为基础的结果可能有助于泌尿科医生评估癌症幸存者患膀胱肿瘤的风险。我们的数据应该指导正在进行的研究，调查膀胱癌筛查在癌症患者中的有效性。
This study quantified the risk of urinary bladder neoplasms in cancer patients taking into account the age at first diagnosis, the gender of the patients and the lead time between diagnoses. We used standardised incidence ratios (SIRs) to compare the incidence of bladder tumours in 967 767 cancer patients with the incidence rate in the general Swedish population. A total of 3324 male and 1560 female patients developed bladder tumours at least 1 year after first cancer diagnosis. After bladder and renal pelvis cancers, the SIRs of bladder neoplasms were higher in female than in male patients. Men affected by lung, stomach and larynx tumours belonged to the population at high risk for bladder cancer. Treatment of breast, ovarian and cervical cancers seems to contribute to the subsequent development of bladder neoplasms. Long latencies (16–25 years) were observed after testicular, cervical and endometrial cancers. Detection bias had an important role after prostate cancer. Chemotherapy with cyclophosphamide and cisplatin, and also radiotherapy, seem to increase the risk of subsequent neoplasms in the bladder. These population-based results may help urologists to assess the risk of bladder neoplasms in cancer survivors. Our data should guide ongoing studies that investigate the effectiveness of bladder cancer screening in cancer patients.
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影响因子：
30.8
作者：
Kiemeney LA;Thorlacius S;Sulem P;Geller F;Aben KK;Stacey SN;Gudmundsson J;Jakobsdottir M;Bergthorsson JT;Sigurdsson A;Blondal T;Witjes JA;Vermeulen SH;Hulsbergen-van de Kaa CA;Swinkels DW;Ploeg M;Cornel EB;Vergunst H;Thorgeirsson TE;Gudbjartsson D;Gudjonsson SA;Thorleifsson G;Kristinsson KT;Mouy M;Snorradottir S;Placidi D;Campagna M;Arici C;Koppova K;Gurzau E;Rudnai P;Kellen E;Polidoro S;Guarrera S;Sacerdote C;Sanchez M;Saez B;Valdivia G;Ryk C;de Verdier P;Lindblom A;Golka K;Bishop DT;Knowles MA;Nikulasson S;Petursdottir V;Jonsson E;Geirsson G;Kristjansson B;Mayordomo JI;Steineck G;Porru S;Buntinx F;Zeegers MP;Fletcher T;Kumar R;Matullo G;Vineis P;Kiltie AE;Gulcher JR;Thorsteinsdottir U;Kong A;Rafnar T;Stefansson K
通讯作者：
Stefansson K
影响因子：
120.7
作者：
Grossman, HB;Messing, E;Shen, Y
通讯作者：
Shen, Y
影响因子：
6.4
作者：
KALDOR, JM;DAY, NE;STORM, HH
通讯作者：
STORM, HH
影响因子：
45.3
作者：
Dores, GM;Metayer, C;Travis, LB
通讯作者：
Travis, LB
影响因子：
6.6
作者：
Bostrom, Peter J.;Soloway, Mark S.;Samavedi, Srinivas
通讯作者：
Samavedi, Srinivas