Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation
Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation
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DOI：
10.1161/01.hyp.0000091371.53502.d3
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发表时间：
2003-10-01
期刊：
影响因子：
8.3
通讯作者：
Tuck, ML
中科院分区：
文献类型：
--
作者：
Masuo, K;Kawaguchi, H;Tuck, ML
据报道，高血压、肥胖症常与高尿酸血症并存。为了阐明体重增加引起的高血压患者的血尿酸、血浆去甲肾上腺素和胰岛素或瘦素水平之间的关系，我们进行了这项纵向研究。对433名血压正常的非肥胖青年男性，连续5年每年测量体重指数、血压、血尿酸、空腹血浆去甲肾上腺素、胰岛素和瘦素水平。受试者按体重显著增加和/或血压升高(体重指数或平均血压上升10%)进行分层，为期5年。入选时，有血压升高的受试者的血压、尿酸和去甲肾上腺素的值高于无高血压的受试者，尽管体重指数、胰岛素和瘦素相似。在进入试验时，体重增加的受试者的体重指数、血压、尿酸和去甲肾上腺素高于没有增加体重的受试者。体重指数、平均血压、尿酸、去甲肾上腺素、胰岛素和瘦素在有血压升高和/或体重增加的受试者5年内的增加幅度大于无高血压和/或体重增加的受试者，其中体重增加且血压升高的受试者的增幅最大。通过多元回归分析，基础平均血压、去甲肾上腺素和尿酸是5年后平均血压变化的显著决定因素，基础体重指数、去甲肾上腺素和尿酸是体重指数变化的显著决定因素。这些结果表明，血尿酸和血浆去甲肾上腺素浓度预测随后的体重增加和血压升高。
It has been reported that hypertension and obesity often coexist with hyperuricemia. To clarify the relations between serum uric acid, plasma norepinephrine, and insulin or leptin levels in subjects with weight gain-induced blood pressure elevation, we conducted the present longitudinal study. In 433 young, nonobese, normotensive men, body mass index, blood pressure, and levels of serum uric acid, fasting plasma norepinephrine, insulin, and leptin were measured every year for 5 years. Subjects were stratified by significant weight gain and/or blood pressure elevation (>10% in body mass index or mean blood pressure) for 5 years. At entry, blood pressure, uric acid, and norepinephrine values in subjects with blood pressure elevation were greater than in those without it, although body mass index, insulin, and leptin were similar. At entry, body mass index, blood pressure, uric acid, and norepinephrine in subjects with weight gain were greater than in those without weight gain. The increases in body mass index, mean blood pressure, uric acid, norepinephrine, insulin, and leptin for 5 years were greater in subjects with blood pressure elevation and/or weight gain than in subjects without, and those increases were greatest in subjects with weight gain whose blood pressure was elevated. By multiple regression analysis, basal mean blood pressure, norepinephrine, and uric acid were significant determinant factors of changes in mean blood pressure over 5 years, and basal body mass index, norepinephrine, and uric acid were significant determinant factors of changes in body mass index. These results demonstrate that serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation.