Heightened connectivity between the ventral striatum and medial prefrontal cortex as a biomarker for stress-related psychopathology: understanding interactive effects of early and more recent stress.
Heightened connectivity between the ventral striatum and medial prefrontal cortex as a biomarker for stress-related psychopathology: understanding interactive effects of early and more recent stress.
复制标题
DOI：
10.1017/s0033291717003348
复制
发表时间：
2018-08
影响因子：
6.9
通讯作者：
Hariri AR
中科院分区：
文献类型：
--
作者：
Hanson JL;Knodt AR;Brigidi BD;Hariri AR
儿童期遭受虐待的经历是抑郁症发展的一个重要危险因素。这种风险在暴露于额外的、更同步的压力之后特别高。虽然存在这种关系的行为证据，但对这些压力相互作用的生物学相关性知之甚少。识别这些相关性可能会提供日后抑郁症风险的生物标志物。在这里，我们利用来自杜克神经遗传学研究的行为、经验和神经影像学数据来识别压力暴露的潜在生物标志物。基于过去的研究，我们特别感兴趣的是与奖励相关的连接以及早期和近期压力的相互作用。我们研究了腹侧纹状体和其他大脑区域之间的心理生理相互作用与这些压力变量，以及内化神经病学的措施（n=926，参与者年龄范围= 18-22岁）。我们发现，在童年遭受过更严重虐待的个体中，左腹侧纹状体和内侧前额叶皮质之间的奖励相关功能连接相对增加，这些个体也经历了更高水平的近期生活压力（β=0.199，p<0.005）。这种功能连接模式进一步与抑郁症状升高相关（β=0.089，p= 0.006）。此外，使用温和的调解框架，我们证明，这种功能连接提供了一个累积的压力暴露和内化的神经病理学之间的生物联系。这些发现表明，一种新的神经生物标志物将累积的压力暴露与后来的抑郁症状联系起来。我们的研究结果进行了讨论的背景下，过去的研究压力暴露与抑郁症的关系。
The experience of childhood maltreatment is a significant risk factor for the development of depression. This risk is particularly heightened after exposure to additional, more contemporaneous stress. While behavioral evidence exists for this relation, little is known about biological correlates of these stress interactions. Identifying such correlates may provide biomarkers of risk for later depression. Here we leverage behavioral, experiential, and neuroimaging data from the Duke Neurogenetics Study to identify potential biomarkers of stress exposure. Based on past research, we were specifically interested in reward-related connectivity and the interaction of early and more recent stress. We examined psychophysiological interactions between the ventral striatum and other brain regions in relation to these stress variables, as well as measures of internalizing symptomatology (n=926, participant age range = 18-22 years of age). We found relatively increased reward-related functional connectivity between the left ventral striatum and the medial prefrontal cortex in individuals exposed to greater levels of childhood maltreatment who also experienced greater levels of recent life stress (β=0.199, p<.005). This pattern of functional connectivity was further associated with elevated symptoms of depression (β=0.089, p=.006). Furthermore, using a moderated mediation framework, we demonstrate that this functional connectivity provides a biological link between cumulative stress exposure and internalizing symptomatology. These findings suggest a novel neural biomarker linking cumulative stress exposure with the later experience of depressive symptoms. Our results are discussed in the context of past research examining stress exposure in relation of depression.