Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases.
Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases.
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DOI：
10.1186/2050-7771-2-1
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发表时间：
2014-01-07
影响因子：
11.1
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Yang J;Zhang L;Yu C;Yang XF;Wang H
单核细胞表达各种受体，监测和感知环境变化。单核细胞是高度可塑性和异质性的，并且响应于环境刺激而改变其功能表型。来自小鼠和人类研究的证据表明，单核细胞增多症可以是各种炎性疾病的指标。单核细胞可以分化成炎症或抗炎亚群。在组织损伤或感染时，单核细胞被迅速募集到组织中，在那里它们可以分化成组织巨噬细胞或树突细胞。鉴于单核细胞在广谱炎症性疾病中的研究进展迅速，有必要总结我们对单核细胞异质性及其在人类疾病中的影响的认识。在这篇综述中，我们描述了目前对人类和小鼠单核细胞异质性的理解，单核细胞不同亚群的功能，以及单核细胞分化的潜在机制。我们强调，炎症单核细胞亚群是炎症性疾病，包括心血管疾病的有价值的生物标志物。
Monocytes express various receptors, which monitor and sense environmental changes. Monocytes are highly plastic and heterogeneous, and change their functional phenotype in response to environmental stimulation. Evidence from murine and human studies has suggested that monocytosis can be an indicator of various inflammatory diseases. Monocytes can differentiate into inflammatory or anti-inflammatory subsets. Upon tissue damage or infection, monocytes are rapidly recruited to the tissue, where they can differentiate into tissue macrophages or dendritic cells. Given the rapid progress in monocyte research from broad spectrum of inflammatory diseases, there is a need to summarize our knowledge in monocyte heterogeneity and its impact in human disease. In this review, we describe the current understanding of heterogeneity of human and murine monocytes, the function of distinct subsets of monocytes, and a potential mechanism for monocyte differentiation. We emphasize that inflammatory monocyte subsets are valuable biomarkers for inflammatory diseases, including cardiovascular diseases.