The role of DNA methylation in the development and progression of lung adenocarcinoma.
The role of DNA methylation in the development and progression of lung adenocarcinoma.
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DOI：
10.1155/2007/985474
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Laird-Offringa IA
中科院分区：
文献类型：
--
作者：
Kerr KM;Galler JS;Hagen JA;Laird PW;Laird-Offringa IA
在美国和西欧，由吸烟引起的肺癌是癌症死亡的主要原因。在∼中，有87%的病例由吸烟引起。腺癌现在是美国男性和女性中最常见的肺癌类型，也是从不吸烟和曾经吸烟的人中最常见的组织亚型。腺癌的发病率增加，它发生在肺部更外围，被认为至少部分与卷烟制造的改进有关，这些改进导致了烟雾吸入深度的变化。肺腺癌发病率的上升及其致命性强调了了解这种疾病的发展和进展的重要性。DNA甲基化的改变被认为是癌症的关键表观遗传学改变，通过全球低甲基化导致染色体不稳定，并通过改变启动子CpG岛的甲基化水平导致基因异常表达。识别肺腺癌进展和转移过程中DNA甲基化的顺序变化，并阐明它们与基因变化的相互作用，将拓宽我们对这种疾病的分子理解，为靶向药物的开发提供见解，以及为早期发现和患者分类提供强大的标记。
Lung cancer, caused by smoking in ∼87% of cases, is the leading cause of cancer death in the United States and Western Europe. Adenocarcinoma is now the most common type of lung cancer in men and women in the United States, and the histological subtype most frequently seen in never-smokers and former smokers. The increasing frequency of adenocarcinoma, which occurs more peripherally in the lung, is thought to be at least partially related to modifications in cigarette manufacturing that have led to a change in the depth of smoke inhalation. The rising incidence of lung adenocarcinoma and its lethal nature underline the importance of understanding the development and progression of this disease. Alterations in DNA methylation are recognized as key epigenetic changes in cancer, contributing to chromosomal instability through global hypomethylation, and aberrant gene expression through alterations in the methylation levels at promoter CpG islands. The identification of sequential changes in DNA methylation during progression and metastasis of lung adenocarcinoma, and the elucidation of their interplay with genetic changes, will broaden our molecular understanding of this disease, providing insights that may be applicable to the development of targeted drugs, as well as powerful markers for early detection and patient classification.
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影响因子：
3.5
作者：
Baylin, SB;Esteller, M;Herman, JG
通讯作者：
Herman, JG
DOI：
10.1073/pnas.95.20.11891
发表时间：
1998-09-29
影响因子：
11.1
作者：
Belinsky, SA;Nikula, KJ;Herman, JG
通讯作者：
Herman, JG
影响因子：
4.7
作者：
Belinsky, SA;Snow, SS;Palmisano, WA
通讯作者：
Palmisano, WA
影响因子：
2.2
作者：
Awaya, H;Takeshima, Y;Inai, K
通讯作者：
Inai, K
影响因子：
8
作者：
Brabender, J;Usadel, H;Danenberg, PV
通讯作者：
Danenberg, PV