Cough and airway disease: The role of ion channels
Cough and airway disease: The role of ion channels
复制标题
DOI：
10.1016/j.pupt.2017.06.009
复制
发表时间：
2017-12-01
影响因子：
3.2
通讯作者：
Belvisi, Maria G.
中科院分区：
文献类型：
--
作者：
Bonvini, Sara J.;Belvisi, Maria G.
咳嗽是患者去看初级保健医生的最常见原因，但它仍然是一个未满足的医疗需求。它可以是特发性的，但也可以是慢性肺部疾病如哮喘，COPD和特发性肺纤维化（IPF）的一个麻烦的症状。慢性咳嗽影响高达12%的人口，但没有安全有效的治疗方法。咳嗽反射由支配气道的迷走感觉传入神经调节。瞬时受体电位（TRP）离子通道家族在感觉神经末梢上表达，并且当被激活时可以引起咳嗽。本文综述了TRP Vannilloid 1（TRPV 1）、TRP Ankyrin 1（TRPA 1）、TRP Vannilloid 4（TRPV 4）和TRP Melastatin 8（TRPM 8）4种TRP通道及其嘌呤能P2X3受体在慢性咳嗽中的作用。我们的结论是，鉴于这些离子通道的表达谱及其在感觉传入和咳嗽反射激活中的作用，它们可能是治疗慢性肺病呼吸道症状的绝佳治疗靶点。(C)2017爱思唯尔有限公司版权所有
Cough is the most common reason for patients to visit a primary care physician, yet it remains an unmet medical need. It can be idiopathic in nature but can also be a troublesome symptom across chronic lung diseases such as asthma, COPD and idiopathic pulmonary fibrosis (IPF). Chronic cough affects up to 12% of the population and yet there are no safe and effective therapies. The cough reflex is regulated by vagal, sensory afferent nerves which innervate the airway. The Transient Receptor Potential (TRP) family of ion channels are expressed on sensory nerve terminals, and when activated can evoke cough. This review focuses on the role of 4 TRP channels; TRP Vannilloid 1 (TRPV1), TRP Ankyrin 1 (TRPA1), TRP Vannilloid 4 (TRPV4) and TRP Melastatin 8 (TRPM8) and the purinergic P2X3 receptor and their possible role in chronic cough. We conclude that these ion channels, given their expression profile and their role in the activation of sensory afferents and the cough reflex, may represent excellent therapeutic targets for the treatment of respiratory symptoms in chronic lung disease. (C) 2017 Elsevier Ltd. All rights reserved.