Modifications of H3K9me2, H3K36me3 and H4K20me2 may be involved in arsenic-induced genetic damage
Modifications of H3K9me2, H3K36me3 and H4K20me2 may be involved in arsenic-induced genetic damage
复制标题
H3K9me2、H3K36me3 和 H4K20me2 的修饰可能与砷诱导的遗传损伤有关
DOI：
10.1039/c6tx00117c
复制
发表时间：
2016-01-01
影响因子：
2.1
通讯作者：
Zhang, Aihua
中科院分区：
文献类型：
--
作者：
Li, Jun;Ma, Lu;Zhang, Aihua
地方性砷中毒是一种世界性疾病，许多研究表明砷具有明显的遗传毒性。然而，砷引起遗传损伤的机制尚不清楚。本研究以贵州省燃煤型砷中毒患者中国为研究对象。通过分析遗传损伤与组蛋白修饰水平之间的关系，并通过比较对照组和砷中毒组，进一步分析它们之间的关系，目的是探讨组蛋白修饰在砷诱导的遗传损伤中的作用。结果表明，砷可抑制H4K20me2和H3K9me2的修饰水平，增加H3K36me3的修饰水平，参与砷诱导的DNA损伤修复。本研究为砷的遗传毒性研究提供了一条新的途径。
Endemic arsenic poisoning is a worldwide disease and many studies show that arsenic has obvious genetic toxicity. However, the mechanism of arsenic-induced genetic damage is unclear. In this study, coal-fired arsenic poisoning patients in the Guizhou Province, China, were selected as research subjects. Through an analysis of the relationship between genetic damage and histone modification levels and by comparing the control and arsenic poisoning groups, further analysis of their relationship was carried out, the aim being to explore the role of histone modification in arsenic-induced genetic damage. The result shows that arsenic may inhibit the modification level of H4K20me2 and H3K9me2, and increase the modification of H3K36me3, involved in the repair of DNA damage induced by arsenic. This study could provide a new pathway for studies of the genetic toxicity of arsenic.