NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder
NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder
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DOI：
10.1016/j.schres.2004.02.016
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发表时间：
2004-12-01
影响因子：
4.5
通讯作者：
Meador-Woodruff, JH
中科院分区：
文献类型：
--
作者：
Mueller, HT;Meador-Woodruff, JH
越来越多的证据表明 NMDA 受体 (NMDAR) 功能障碍可能与精神分裂症有关。 NMDAR 是源自七个不同基因（NR1、NR2A-2D 和 NR3A-3B）的多聚体组装体。虽然精神分裂症中大多数 NMDAR 亚基的表达存在区域特异性变化，但尚未研究 NR3A 表达可能的异常。然而，啮齿类动物的电生理学和解剖学数据表明，NR3A 亚基可能在这种疾病中发挥作用。在这项研究中，我们测量了精神分裂症、双相情感障碍、抑郁症患者和对照组的背外侧前额叶皮层 (DLPFC) 和颞下新皮层的 NR3A 转录水平。与对照组相比，精神分裂症患者的这一转录本升高了 32%，但仅限于 DLPFC，而不是下颞皮质区域。有趣的是，这种效应仅限于 DLPFC 的回旋部分，不涉及脑沟区域。与 DLPFC 中的对照组相比，双相情感障碍中的 NR3A mRNA 显着降低 12%，尽管脑回与脑沟之间没有差异。与精神分裂症的情况一样，双相情感障碍患者的颞下皮层中没有观察到 NR3A 表达的变化。这些数据表明NR3A亚基在精神分裂症和双相情感障碍中异常表达。 (C) 2004 Elsevier B.V. 保留所有权利。
Growing evidence suggests that NMDA receptor (NMDAR) dysfunction may be involved in schizophrenia. The NMDAR is a multimeric assembly derived from seven different genes (NR1, NR2A-2D and NR3A-3B). While region-specific changes in the expression of most NMDAR subunits have been reported in schizophrenia, possible abnormalities of NR3A expression have not been investigated. Both electrophysiological and anatomical data in rodents, however, suggest that NR3A subunits could play a role in this disorder. In this study, we measured NR3A transcript levels in the dorsolateral prefrontal cortex (DLPFC) and inferior temporal neocortex in the brains of people with schizophrenia, bipolar disorder, depression, and a comparison group. This transcript was elevated by 32% in schizophrenia relative to controls, but only in the DLPFC and not inferior temporal cortical regions. Interestingly, this effect was restricted to gyral aspects of the DLPFC and did not involve sulcal areas. NR3A mRNA was significantly decreased by 12% in bipolar disorder relative to the comparison group in DLPFC, although there were no gyral versus sulcal differences. As was the case in schizophrenia, no changes in NR3A expression were observed in the inferior temporal cortex in bipolar disorder. These data indicate that the NR3A subunit is abnormally expressed in both schizophrenia and bipolar disorder. (C) 2004 Elsevier B.V. All rights reserved.