Abnormal body composition phenotypes in older rheumatoid arthritis patients: Association with disease characteristics and pharmacotherapies
Abnormal body composition phenotypes in older rheumatoid arthritis patients: Association with disease characteristics and pharmacotherapies
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DOI：
10.1002/art.23719
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发表时间：
2008-06-15
期刊：
影响因子：
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通讯作者：
Bathon, Joan M.
中科院分区：
文献类型：
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作者：
Giles, Jon T.;Ling, Shari M.;Bathon, Joan M.
Objective.比较男性和女性类风湿性关节炎（RA）患者与对照组的体脂和瘦体重指标以及异常身体组成表型（少肌症、肥胖和少肌性肥胖）的患病率，并探讨RA患者异常身体组成的疾病相关预测因素。共有189名男性和女性RA患者和189名年龄、性别和种族匹配的非RA对照者接受双能X线吸收测定法测量总的和局部的体脂和瘦体重。按性别和体重指数（BMI）分类比较RA和对照组受试者的连续和分类身体成分测量结果。在RA患者组内，比较健康体成分与异常体成分表型RA患者的人口统计学、生活方式、RA疾病和治疗特征。与非RA对照组相比，RA状态与女性中肌肉减少症、过胖和肌肉减少性肥胖的几率更大显著相关，但与男性无关。RA和对照受试者之间身体组成表型的相对差异在正常体重BMI类别的患者中最大（
Objective. To compare measures of body fat and lean mass and the prevalence of abnormal body composition phenotypes (sarcopenia, overfat, and sarcopenic obesity) in men and women with rheumatoid arthritis (RA) versus matched controls, and to explore the disease-related predictors of abnormal body composition in patients with RA.Methods. A total of 189 men and women with RA and 189 age-, sex-, and race-matched non-RA controls underwent dual-energy x-ray absorptiometry for measurement of total and regional body fat and lean mass. Continuous and categorical measures of body composition were compared between RA and control subjects by sex anti according to categories of body mass index (BMI). Within the group of RA patients, demographic, lifestyle, and RA disease and treatment characteristics were compared for RA patients with healthy body composition versus those with abnormal body composition phenotypes.Results. Compared with non-RA controls, RA status was significantly associated with greater odds of sarcopenia, overfat, and sarcopenic obesity in women, but not in men. Relative differences in body composition phenotypes between RA and control subjects were greatest for patients in the normal weight BMI category (