Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism.
Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism.
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DOI：
10.1039/b915852a
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发表时间：
2010-03
影响因子：
4.9
通讯作者：
Junfeng Wang;Xin Wang;Z. Ge;T. Cheng;Runtao Li
中科院分区：
文献类型：
--
作者：
Junfeng Wang;Xin Wang;Z. Ge;T. Cheng;Runtao Li
采用一种简单易行的手性1,2-二氨基环己烷-己二酸催化了环戊酮与查尔酮的高效非对称Michael加成反应，反应收率高达92%，对映选择性高达99% ee。提出了一种新的二胺反应机理。
The highly efficient asymmetric Michael addition reactions of cyclopentanone with chalcones were catalyzed by a simple and commercially available chiral 1,2-diaminocyclohexane-hexanedioic acid, and exhibited good yields (up to 92%) and excellent enantioselectivities (up to 99% ee). A new di-iminium mechanism for the reaction was proposed.