Carotid plaque pathology - Thrombosis, ulceration, and stroke pathogenesis
Carotid plaque pathology - Thrombosis, ulceration, and stroke pathogenesis
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DOI：
10.1161/01.str.0000152336.71224.21
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发表时间：
2005-02-01
期刊：
影响因子：
8.3
通讯作者：
Norris, J
中科院分区：
文献类型：
--
作者：
Fisher, M;Paganini-Hill, A;Norris, J
背景和目的-为了确定颈动脉粥样硬化斑块的溃疡、血栓和钙化与同侧或对侧stroke. Methods症状之间的关系，我们比较了同侧或对侧有和无卒中症状患者的斑块微观形态。斑块的特征为溃疡、血栓和钙化。我们分析了来自241名受试者的斑块：170名患者参加了无症状颈动脉粥样硬化研究（ACAS），71名患者参加了北美症状性颈动脉内膜切除术试验（NASCET）; 128例受试者无卒中症状史，80例受试者有同侧症状，33例有对侧症状。结果-斑块溃疡在有症状患者的斑块中比无症状患者更常见（36%比14%; P
Background and Purpose-To determine the relationship between ulceration, thrombus, and calcification of carotid artery atherosclerotic plaques and symptoms of ipsilateral or contralateral stroke.Methods-We compared microscopic plaque morphology from patients with and without stroke symptoms ipsilateral or contralateral to the plaque. Plaques were characterized for ulceration, thrombus, and calcification. We analyzed plaques from 241 subjects: 170 patients enrolled in the Asymptomatic Carotid Atherosclerosis Study ( ACAS) and 71 patients enrolled in the North American Symptomatic Carotid Endarterectomy Trial (NASCET); 128 subjects had no history of stroke symptoms, 80 subjects had ipsilateral symptoms, and 33 had contralateral symptoms.Results-Plaque ulceration was more common in plaques taken from symptomatic patients than those without symptoms (36% versus 14%; P