Measurement of central corneal thickness using Orbscan 3, Pentacam HR and ultrasound pachymetry in normal eyes
Measurement of central corneal thickness using Orbscan 3, Pentacam HR and ultrasound pachymetry in normal eyes
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DOI：
10.1007/s10792-020-01344-1
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发表时间：
2020-03-27
影响因子：
1.6
通讯作者：
Othman, Ihab Saad
中科院分区：
文献类型：
--
作者：
Gharieb, Hesham Mohamed;Ashour, Doaa Maamoun;Othman, Ihab Saad
目的评价Orbscan 3、Pentacam HR和超声测厚仪（Palm Scan ap2000）测量角膜中央厚度的一致性。方法对48例正常角膜患者92只眼进行前瞻性横断面观察。采用Pentacam HR、Orbscan 3和超声测厚仪测量角膜中央厚度。使用Bland-Altman分析来证明各种方法之间的一致性。结果纳入受试者46例，92只眼。平均年龄29.67岁（18-59岁）。Pentacam HR、Orbscan和超声波测得的角膜中央厚度平均值分别为545.73 +/- 29.35 μ m、549.34 +/- 29.14 μ m和545.78 +/- 31.48 μ m。三种仪器的测量值密切相关，Pearson相关系数为0.868 ~ 0.929。Orbscan和Pentacam角膜中央厚度的95%一致性范围为25.2 ~ - 18 μ m， Pentacam和pachymetry角膜中央厚度的95%一致性范围为25.2 ~ - 25.7 μ m， Orbscan和pachymetry角膜中央厚度的95%一致性范围为34.4 ~ - 27.2 μ m。结论尽管Orbscan 3取得了进步，但通过Orbscan 3、Pentacam HR和超声测厚仪获得的CCT测量结果之间仍然存在广泛的一致限制；因此，不建议在临床实践中互换使用。
Purpose To assess the agreement between Orbscan 3, Pentacam HR and ultrasound pachymetry (Palm Scan AP 2000) in measuring central corneal thickness. Methods Prospective observational cross-sectional study of ninety-two eyes of 48 patients with normal corneas was conducted. Central corneal thickness was measured via Pentacam HR, Orbscan 3 and ultrasound pachymetry. Bland-Altman analysis was used to demonstrate agreement between various methods. Results Ninety-two eyes of 46 subjects were enrolled. The mean age was 29.67 years (18-59). The average measurements of central corneal thickness were 545.73 +/- 29.35 mu m, 549.34 +/- 29.14 mu m and 545.78 +/- 31.48 mu m for the Pentacam HR, Orbscan and ultrasound pachymetry, respectively. The three devices measurements are closely correlated, with Pearson correlation coefficient ranging from 0.868 to 0.929. The 95 % limits of agreement were 25.2 to - 18 mu m between Orbscan and Pentacam central corneal thickness, 25.2 to - 25.7 mu m between Pentacam and pachymetry central corneal thickness and 34.4 to - 27.2 mu m between Orbscan and pachymetry central corneal thickness. Conclusion In spite of advancement of Orbscan 3, still there are wide agreement limits between CCT measurements obtained via Orbscan 3, Pentacam HR and ultrasound pachymetry; thus, interchangeable use in clinical practice is not recommended.