Basolateral amygdala lesions abolish orbitofrontal-dependent reversal impairments
Basolateral amygdala lesions abolish orbitofrontal-dependent reversal impairments
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DOI：
10.1016/j.neuron.2007.02.014
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发表时间：
2007-04-05
期刊：
影响因子：
16.2
通讯作者：
Schoenbaum, Geoffrey
中科院分区：
文献类型：
--
作者：
Stalnaker, Thomas A.;Franz, Theresa M.;Schoenbaum, Geoffrey
眶额皮质（OFC）的损伤长期以来与逆转学习的缺陷有关。在反向学习过程中，眶额皮层损伤也会导致基底外侧杏仁核（ABL）的不灵活的联想编码。在这里，我们提供了一个关键的测试的假设，即在OFC损伤的大鼠的逆转赤字是由这种不灵活的编码在ABL。大鼠双侧神经毒性病变的OFC，ABL，或两个领域进行了测试，对一系列的两个气味去/不去的歧视问题，其次是两个系列逆转的最后一个问题。正如预期的那样，所有组以相同的速率获得初始问题，并且具有OFC损伤的大鼠比假对照组更慢地获得逆转。伴随ABL病变，这种损害被取消，而ABL病变单独逆转学习没有影响。这些结果与OFC通过促进下游脑区联想编码的更新来促进认知灵活性的假设是一致的。
Damage to orbitofrontal cortex (OFC) has long been associated with deficits in reversal learning. OFC damage also causes inflexible associative encoding in basolateral amygdala (ABL) during reversal learning. Here we provide a critical test of the hypothesis that the reversal deficit in OFC-lesioned rats is caused by this inflexible encoding in ABL. Rats with bilateral neurotoxic lesions of OFC, ABL, or both areas were tested on a series of two-odor go/no-go discrimination problems, followed by two serial reversals of the final problem. As expected, all groups acquired the initial problems at the same rate, and rats with OFC lesions were slower to acquire the reversals than sham controls. This impairment was abolished by accompanying ABL lesions, while ABL lesions alone had no effect on reversal learning. These results are consistent with the hypothesis that OFC facilitates cognitive flexibility by promoting updating of associative encoding in downstream brain areas.