Prospective Evaluation of the Association Between Arthritis and Cognitive Functions in Middle-Aged and Elderly Chinese.
Prospective Evaluation of the Association Between Arthritis and Cognitive Functions in Middle-Aged and Elderly Chinese.
复制标题
中国中老年人关节炎与认知功能关系的前瞻性评估
DOI：
10.3389/fnagi.2021.687780
复制
发表时间：
2021
影响因子：
4.8
通讯作者：
Pan XF
中科院分区：
文献类型：
--
作者：
Liu W;Yang X;Jin X;Xiu P;Wen Y;Wu N;Zhao J;Zhou D;Pan XF
背景：评估关节炎和认知损害之间的关系可以扩大对关节炎健康后果的理解。其目的是前瞻性地研究中国中老年人群中关节炎与认知功能之间的关系。方法：我们的分析基于2011年至2016年全国中国健康与退休纵向研究的数据。在基线调查期间，通过自我报告的医生诊断来确定关节炎。认知功能从情景记忆、心理状态和全局认知三个领域进行评估。线性混合模型被用来评估基线关节炎和认知功能之间的关联。结果：7529名中国成年人中，男性占49.79%，平均年龄为57.53岁。在4年的随访中，与非关节炎患者相比，基线关节炎患者的情景记忆[β=−0.08；95%可信区间(CI)：−0.14，−0.03]、精神状态(β=−0.14；95%CI：−0.22，−0.05)和整体认知(β=−0.22；95%CI：−0.34，−0.11)得分较低。此外，患有关节炎的参与者的精神状态和全球认知下降的速度每年分别增加0.04(95%CI：0.01，0.08)和0.05(95%CI：0.01，0.09)个单位。结论：在中国中老年人中，关节炎与认知功能较差和认知功能略快下降的风险相关。我们的发现应该在未来在中国和其他人群中进行的大型前瞻性研究中得到证实。
Background: Assessing the relation between arthritis and cognitive impairment could expand the understanding of health consequences of arthritis. The aim was to prospectively examine the association between arthritis and cognitive functions among middle-aged and elderly Chinese. Methods: Our analyses were based on data from the nationwide China Health and Retirement Longitudinal Study (2011–2016). Arthritis was ascertained by self-reported doctor diagnosis during the baseline survey. Cognitive functions were evaluated in three domains including episodic memory, mental status, and global cognition. Linear mixed models were employed to assess the association between baseline arthritis and cognition functions. Results: Of 7,529 Chinese adults, 49.79% were men, and mean age was 57.53 years. During a follow-up of 4 years, participants with baseline arthritis showed lower scores of episodic memory [β = −0.08; 95% confidence interval (CI): −0.14, −0.03], mental status (β = −0.14; 95% CI: −0.22, −0.05), and global cognition (β = −0.22; 95% CI: −0.34, −0.11), compared to those without arthritis. In addition, participants with arthritis showed increased rates of decline in mental status and global cognition by 0.04 (95% CI: 0.01, 0.08) and 0.05 (95% CI: 0.01, 0.09) units per year, respectively. Conclusion: Arthritis was associated with subsequent risk of poorer cognitive functions and slightly faster declines in cognitive functions among Chinese middle-aged and elderly adults. Our findings should be confirmed in future large prospective studies in Chinese and other populations.
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DOI：
10.1186/s13195-018-0355-1
发表时间：
2018-03-12
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Sha T;Cheng W;Yan Y
通讯作者：
Yan Y
DOI：
10.1016/j.jalz.2016.12.013
发表时间：
2017-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Bender AC;Austin AM;Grodstein F;Bynum JPW
通讯作者：
Bynum JPW
影响因子：
3.7
作者：
Lin TM;Chen WS;Sheu JJ;Chen YH;Chen JH;Chang CC
通讯作者：
Chang CC
DOI：
10.1038/nrrheum.2016.112
发表时间：
2016-09
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
Sturgeon JA;Finan PH;Zautra AJ
通讯作者：
Zautra AJ
影响因子：
64.3
作者：
Huang, Yueqin;Wang, Yu;Wu, Yue
通讯作者：
Wu, Yue