Nanoparticles of hydrophobically modified dextrans as potential drug carrier systems
Nanoparticles of hydrophobically modified dextrans as potential drug carrier systems
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DOI：
10.1016/j.colsurfb.2007.04.021
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发表时间：
2007-09-01
影响因子：
5.8
通讯作者：
Leonard, M.
中科院分区：
文献类型：
--
作者：
Aumelas, A.;Serrero, A.;Leonard, M.
结合疏水改性的葡聚糖核心和多糖表面覆盖的纳米颗粒进行了阐述。他们的适用性，如药物输送的应用进行了评估。选择的多糖，葡聚糖，通过共价连接的烃基（脂肪族或芳香族）通过醚键的形成进行化学修饰。根据改性程度的不同，可以得到水溶性或水不溶性的葡聚糖衍生物。后者在有机溶剂如四氢呋喃或用水饱和的二氯甲烷中表现出溶解性。水溶性葡聚糖衍生物被用作控制纳米颗粒表面特性的聚合物表面活性剂。纳米粒子的制备通过O/W乳液或溶剂扩散法。葡聚糖纳米颗粒的尺寸和表面性质与加工条件相关。胶体悬浮液的稳定性进行了检查作为离子强度的函数和相关的颗粒表面特性。证明了不添加冷冻保护剂的冷冻干燥混悬液的再分散性。最后，在葡聚糖酶的存在下酶促水解后，将改性葡聚糖的降解性与起始葡聚糖的降解性进行比较。(C)2007 Elsevier B. V.保留所有权利。
Nanoparticles combining a hydrophobically modified dextran core and a polysaccharide surface coverage were elaborated. Their suitability for applications like drug delivery was evaluated. The selected polysaccharide, dextran, was chemically modified by the covalent attachment of hydrocarbon groups (aliphatic or aromatic) via the formation of ether links. According to the extent of modification, either water-soluble or water-insoluble dextran derivatives were obtained. The latter exhibited solubility in organic solvents like tetrahydroftiran or dichloromethane saturated with water. Water-soluble dextran derivatives were used as polymeric surfactants for the control of nanoparticles surface characteristics. Nanoparticles were prepared either by o/w emulsion or solvent-diffusion methods. The size and surface properties of dextran nanoparticles were correlated to processing conditions. The stability of colloidal suspensions was examined as a function of ionic strength and related to the particle surface characteristics. The redispersability of freeze-dried suspensions without the addition of cryoprotectant was demonstrated. Finally, the degradability of modified dextrans was compared to that of starting dextran, after enzymatic hydrolysis in the presence of dextranase. (C) 2007 Elsevier B.V. All rights reserved.