Age-Related Association between Apolipoprotein E ε4 and Cognitive Function in Japanese Patients with Alzheimer's Disease.
Age-Related Association between Apolipoprotein E ε4 and Cognitive Function in Japanese Patients with Alzheimer's Disease.
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DOI：
10.1159/000348351
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发表时间：
2013-01
影响因子：
2.3
通讯作者：
Yamada H
中科院分区：
文献类型：
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作者：
Nagata T;Shinagawa S;Kuerban B;Shibata N;Ohnuma T;Arai H;Nakayama K;Yamada H
在本研究中，我们调查了载脂蛋白E(APOE)基因多态性是否会影响某些年龄段的日本阿尔茨海默病(AD)患者的认知功能。在2 0 0例门诊痴呆和遗忘型轻度认知障碍患者中，13 3例日本AD患者被分为两组：ApoEε4携带者和非携带者。然后，我们比较了两个不同世代：70岁(70-79岁)和80-89岁(80-89岁)的两个基因组间的神经心理测试得分。在80岁以上的患者中，ε4携带者的简明智力状态检查总分(P<；005)及其其中一个分测验的3阶段命令分数(P<；001)显著低于非携带者，但在70岁以上的患者中没有显著差异。在80多岁的受试者中，ε4携带者和非携带者的病程有显着差异，但与认知功能无关。目前的结果表明，APOE可能显著影响某些世代的日本AD患者相对简单的记忆加工。
In the present study, we investigated whether apolipoprotein E (APOE) polymorphisms influenced the cognitive function of Japanese patients with Alzheimer's disease (AD) at certain ages. Among 200 outpatients with dementia and amnestic mild cognitive impairment, 133 Japanese patients with AD were recruited and divided into two genotypic groups: APOE ε4 carriers and noncarriers. Then, we compared several neuropsychological test scores between the two genotypic groups for two different generations: 70s (70-79 years) and 80s (80-89 years). The total Mini-Mental State Examination score (p < 0.05) and one of its subtest scores, the 3-stage command score (p < 0.01), were significantly lower for the ε4 carriers than for the noncarriers among patients in their 80s, but not among those in their 70s. The duration of illness differed significantly between the ε4 carriers and the noncarriers among subjects in their 80s but was not correlated with cognitive function. The present results suggest that APOE may significantly influence comparatively simple memory processing in certain generations of Japanese patients with AD.