Serum thrombomodulin as a metastatic and prognostic marker in soft tissue sarcomas
Serum thrombomodulin as a metastatic and prognostic marker in soft tissue sarcomas
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DOI：
10.3233/cbm-182075
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发表时间：
2019-01-01
影响因子：
3.1
通讯作者：
Sudo, Akihiro
中科院分区：
文献类型：
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作者：
Asanuma, Kunihiro;Nakamura, Tomoki;Sudo, Akihiro
背景技术背景：血栓调节蛋白（TM）具有多种生物学功能，不仅调节抗凝，而且调节细胞增殖、粘附和抗炎活性。TM的主要功能是激活蛋白C的抗凝途径。可溶性TM是通过其失活的thrombin. ATTIVES转移相关：为了澄清血清TM水平和临床pathologicalparameters.METHODS之间的相关性：血浆TM水平（FU/ml）的135原发性软组织肿瘤（良性，67;软组织肉瘤（STS），68）活检或治疗前进行了测定。分析TM水平并与各种临床病理参数进行比较。对数秩检验和考克斯比例分析被用来评估无复发生存，无转移生存，和总survival.Results：STS肿瘤有显着较高的TM值（15.9）比良性肿瘤（13.7）（p = 0.0138）。5-1-3级低TM组和高TM组的5年MFS分别为81.1%和40.0%（p = 0.00671），低TM组和高TM组的5年OS分别为85.5%和52.5%（p = 0.0673）。在多因素考克斯比例分析中，高TM在1- 3级中显示出显著性差异（MFS：HR 4.37，p = 0.0147; OS：HR 3.60，p = 0.0557）。结论：我们证明高水平的可溶性TM有可能是STS患者转移和预后不良的重要预测因子。TM是高转移潜能的候选分子标志物，并且可用于指导临床治疗策略。
BACKGROUND: Thrombomodulin (TM) has multiple biological functions and modulates not only anti-coagulation, but also cell proliferation, adhesion, and anti-inflammation activities. The main function of TM is to activate the anticoagulant pathway of protein C. Soluble TM is related to metastasis by its inactivation of thrombin.OBJECTIVES: To clarify the correlation between serum TM levels and clinicopathological parameters.METHODS: The plasma TM levels (FU/ml) of 135 primary soft tissue tumors (benign, 67; soft tissue sarcoma (STS), 68) were measured before biopsy or treatment. TM levels were analyzed and compared to various clinicopathological parameters. Log-rank test and Cox proportional analysis were used to evaluate recurrence-free survival, metastasis-free survival, and overall survival.RESULTS: STS tumors had significantly higher TM values (15.9) than benign tumors (13.7) ( p = 0.0138). 5-year MFS was 81.1% in low TM and 40.0% in high TM ( p = 0.00671), and 5-year OS was 85.5% in low and 52.5% in high TM in grades 1-3 (p = 0.0673). In multivariate COX proportional analysis, high-TM showed a significant difference (MFS: HR 4.37, p = 0.0147; OS: HR 3.60, p = 0.0557) in grades 1-3.CONCLUSIONS: We demonstrated that a high level of soluble TM has the potential to be a significant predictor of metastasis and poor prognosis in STS patients. TM is a candidate molecular marker for high metastatic potential and can be clinically useful for guiding therapeutic strategy.