Acute effects of elevated NEFA on vascular function: a comparison of SFA and MUFA.
Acute effects of elevated NEFA on vascular function: a comparison of SFA and MUFA.
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DOI：
10.1017/s0007114510004976
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发表时间：
2011-05
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影响因子：
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通讯作者：
K. Newens;A. Thompson;K. Jackson;John W. Wright;Christine M. Williams
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文献类型：
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作者：
K. Newens;A. Thompson;K. Jackson;John W. Wright;Christine M. Williams
有新的证据表明，高水平的NEFA有助于内皮功能障碍和胰岛素敏感性受损。然而，NEFA构成的影响仍不清楚。共有10名健康男性在不同场合饮用含有50克棕榈硬脂（富含SFA）或高油酸向日葵籽油（富含MUFA）的测试饮料;第三天不含脂肪作为对照。将脂肪乳化到巧克力饮料中，并在基线时作为推注（约10 g脂肪）给予，然后在整个6小时研究日每30分钟给予少量（约3 g脂肪）。推注后2小时开始静脉输注肝素，导致循环NEFA水平较基线增加3 - 4倍。与对照组相比，使用SFA（P <0.001）而非MUFA（P = 0.089）时，通过数字容积脉搏测量的平均动脉硬度更高。与对照组相比，在两种脂肪的消耗过程中，胰岛素和胃抑制肽的总体反应更大（P <0.001）;与SFA不同，MUFA有第二个胰岛素峰值。SFA组330 min时可溶性细胞间粘附分子1（sI-CAM）水平显著高于MUFA组和对照组（P ≤ 0.048）。试验饮料对葡萄糖、总亚硝酸盐、纤溶酶原激活物抑制剂-1或内皮素-1浓度没有影响。本研究表明，来自SFA消耗的NEFA升高对动脉僵硬度和sI-CAM水平有潜在的负面影响。需要更多的研究来充分调查NEFA成分对CVD危险因素的影响。
There is emerging evidence to show that high levels of NEFA contribute to endothelial dysfunction and impaired insulin sensitivity. However, the impact of NEFA composition remains unclear. A total of ten healthy men consumed test drinks containing 50 g of palm stearin (rich in SFA) or high-oleic sunflower oil (rich in MUFA) on separate occasions; a third day included no fat as a control. The fats were emulsified into chocolate drinks and given as a bolus (approximately 10 g fat) at baseline followed by smaller amounts (approximately 3 g fat) every 30 min throughout the 6 h study day. An intravenous heparin infusion was initiated 2 h after the bolus, which resulted in a three- to fourfold increase in circulating NEFA level from baseline. Mean arterial stiffness as measured by digital volume pulse was higher during the consumption of SFA (P < 0·001) but not MUFA (P = 0·089) compared with the control. Overall insulin and gastric inhibitory peptide response was greater during the consumption of both fats compared with the control (P < 0·001); there was a second insulin peak in response to MUFA unlike SFA. Consumption of SFA resulted in higher levels of soluble intercellular adhesion molecule-1 (sI-CAM) at 330 min than that of MUFA or control (P ≤ 0·048). There was no effect of the test drinks on glucose, total nitrite, plasminogen activator inhibitor-1 or endothelin-1 concentrations. The present study indicates a potential negative impact of elevated NEFA derived from the consumption of SFA on arterial stiffness and sI-CAM levels. More studies are needed to fully investigate the impact of NEFA composition on risk factors for CVD.