Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses correlate with control of acute HIV-1 infection in macaques
Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses correlate with control of acute HIV-1 infection in macaques
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DOI：
10.1086/514112
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发表时间：
1997-11-01
影响因子：
6.4
通讯作者：
Zhao, A
中科院分区：
文献类型：
--
作者：
Kent, SJ;Woodward, A;Zhao, A
该模型研究了辅助T细胞（Th）和细胞毒性T细胞（CTL）在控制外周血和淋巴结单核细胞（PBMC和LNMC）急性HIV-1感染中的作用，在HIV-1感染后2周内检测到Th和CTL对HIV-1的反应，CTL对HIV-1抗原的反应在感染后4周达到峰值（bbb100 hiv特异性CTL/10(6) PBMC）。与外周血中HIV-1 RNA和DNA水平的降低一致，HIV-1特异性Th和CTL在感染后6周出现在LNMC中，尽管在感染后2周检测到HIV-1抗体，但直到接种后13周才产生最大的HIV-1抗体反应，因此，T细胞反应与猴体内HIV-1的对照有暂时的相关性。持久的Th反应可能促进了hiv -l特异性CTL反应的快速诱导。
Macaca nemestrina efficiently control acute human immunodeficiency virus type 1 (HIV-I) infection, The roles of helper (Th) and cytotoxic (CTL) T cells in controlling acute HIV-1 infection in both peripheral blood and lymph node mononuclear cells (PBMC and LNMC) were assessed in this model, Th and CTL responses to HIV-1 were detected within 2 weeks following HIV-1 infection, and CTL responses to HIV-1 antigens peaked at 4 weeks after infection (>100 HIV-specific CTL/10(6) PBMC), coincident with reductions of HIV-1 RNA and DNA levels in peripheral blood, HIV-l-specific Th and CTL were present in LNMC 6 weeks after infection, Although HIV-1 antibodies were detected 2 weeks after infection, maximal HIV-1 antibody responses were not generated until > 13 weeks after inoculation, Thus, T cell responses temporally correlate with control of HIV-1 in macaques. The induction of a brisk HIV-l-specific CTL response may have been facilitated by a persistent Th response.