DIETARY-SODIUM, CALCIUM, AND POTASSIUM, AND BLOOD-PRESSURE
DIETARY-SODIUM, CALCIUM, AND POTASSIUM, AND BLOOD-PRESSURE
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DOI：
10.1093/oxfordjournals.aje.a114332
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发表时间：
1986-06-01
影响因子：
5
通讯作者：
VANDERHEIDE, RM
中科院分区：
文献类型：
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作者：
KOK, FJ;VANDENBROUCKE, JP;VANDERHEIDE, RM
收缩压与膳食钠、钙和钾的横截面关联，根据饮食史估计，通过对20世纪50年代初在荷兰收集的2，291名中年公务员及其配偶的一般健康检查数据进行多元回归分析进行了研究。在男性和女性中，即使在对协变量进行调整后，也观察到钙摄入量与收缩压呈统计学显著负趋势。对于钠和钾的摄入量，多变量分析后观察到的负趋势不显著。此外，在多变量分析后，舒张压和微量营养素之间没有一致的关联，除了与女性钙摄入量显著负相关。在该研究人群中，血压是总死亡率的强独立危险因素：高血压患者的15年和25年死亡率约为高血压患者的两倍（≥ 100%）。血压正常者（< 160 mmHg）。这些发现支持了最近流行病学研究的结论，即钙的摄入量增加与收缩压降低有关，并将证据扩展到更早的时间段。
The cross-sectional association of systolic blood pressure with dietary sodium, calcium, and potassium, as estimated from dietary histories, was investigated by multiple regression analysis of data gathered in the Netherlands in the early 1950s in a general health examination of 2,291 middle-aged civil servants and spouses of civil servants. A statistically significant negative trend with systolic blood pressure was seen for calcium intake in both males and females, even after adjustments for covariates. For sodium and potassium intake, the observed negative trends were not significant after multivariate analyses. In addition, no consistent associations were found between diastolic blood pressure and the micronutrients after multivariate analyses, except for a significant negative association with calcium intake in females. In this study population, blood pressure was a strong independent risk factor of total mortality: 15- and 25-year mortality was about twice as high for hypertensives (.gtoreq. 160 mmHg) as for normotensives (< 160 mmHg). These findings support the conclusion in recent epidemiologic studies that higher intakes of calcium are associated with lower systolic blood pressure, and they extend the evidence to an earlier time period.