Effect of polychlorinated biphenyls on the immune responses of rhesus monkeys and mice.
Effect of polychlorinated biphenyls on the immune responses of rhesus monkeys and mice.
复制标题
多氯联苯对恒河猴和小鼠免疫反应的影响。
DOI：
10.1016/0041-008x(78)90282-x
复制
发表时间：
1978
影响因子：
3.8
通讯作者：
R. Hinsdill
中科院分区：
文献类型：
--
作者：
P. Thomas;R. Hinsdill
雌性恒河猴喂食正常食物或含有2.5或5.0 ppm Aroclor 1248（PCB）的食物。6个月后，喂食多氯联苯的猴子出现氯痤疮、脱发和面部水肿。11个月后，对照组和治疗组猴用绵羊红细胞（SRBC）和破伤风类毒素（TT）免疫。喂食5.0 ppm PCB的猴子在初次免疫后仅两个时间间隔内的抗SRBC抗体滴度显著低于对照组。对TT的抗体反应没有受到PCB暴露的影响。两个多氯联苯喂养组的γ-球蛋白水平始终低于对照组。这些结果表明，持续暴露于低水平的PCB可能会产生适度至轻微的免疫抑制作用，这可能取决于个人的总体健康状况。小鼠喂食1000 ppm的多氯联苯3至5周，除肝脏肥大外，没有表现出多氯联苯中毒的迹象。然而，这些小鼠，当挑战与鼠伤寒沙门氏菌，显示出更高的死亡率和显着更多的活菌在脾脏，肝脏和血液中比对照组。同样，暴露的小鼠显示出对内毒素的敏感性增加。因此，暴露于亚临床剂量PCB的小鼠（即，剂量不足以产生明显的中毒临床症状）似乎具有受损的抵抗病原体攻击的能力和增加的对内毒素的敏感性。
Female rhesus monkeys were fed either normal chow or chow containing 2.5 or 5.0 ppm of Aroclor 1248 (PCB). After 6 months, the PCB-fed monkeys developed chloracne, alopecia, and facial edema. After 11 months, control and treated monkeys were immunized with sheep red blood cells (SRBCs) and tetanus toxoid (TT). Monkeys fed 5.0 ppm of PCB had significantly lower anti-SRBC antibody titers than controls at only two intervals following primary immunization. Antibody response to TT was not measurably affected by PCB exposure. Both PCB-fed groups had consistently lower γ-globulin levels than controls. These results indicate that sustained exposure to low levels of PCB could have modest to slight immunosuppressive effects, which might be important depending on the general health of the individual. Mice fed up to 1000 ppm of PCB for 3 to 5 weeks exhibited no signs of PCB intoxication other than liver hypertrophy. However, these mice, when challenged with Salmonella typhimurium, showed higher mortality and significantly greater numbers of viable organisms in the spleen, liver, and blood than did controls. Similarly, exposed mice showed an increased sensitivity to endotoxin. Thus, mice exposed to subclinical doses of PCB (i.e., doses insufficient to produce overt clinical signs of intoxication) appear to have an impaired ability to withstand challenge by pathogens and an increased sensitivity to endotoxin.