MOVEMENT OF MONOCARBOXYLIC ACIDS ACROSS PHOSPHOLIPID MEMBRANES - EVIDENCE FOR AN EXCHANGE DIFFUSION BETWEEN PYRUVATE AND OTHER MONOCARBOXYLATE IONS
MOVEMENT OF MONOCARBOXYLIC ACIDS ACROSS PHOSPHOLIPID MEMBRANES - EVIDENCE FOR AN EXCHANGE DIFFUSION BETWEEN PYRUVATE AND OTHER MONOCARBOXYLATE IONS
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DOI：
10.1016/0005-2736(74)90325-3
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发表时间：
1974-01-01
期刊：
影响因子：
--
通讯作者：
VANDAM, K
中科院分区：
文献类型：
--
作者：
BAKKER, EP;VANDAM, K
在莫能菌素的存在下，丙酮酸钠、乳酸钠、乙酰乙酸钠和β-羟基丁酸钠以有效性递增的顺序渗透通过脂质体膜。通过加入莫能菌素或其他单羧酸盐，脂质体中的丙酮酸钠可以释放到培养基中。后一个过程是两种化合物在没有转运蛋白的帮助下穿过膜的交换扩散的证明。
In the presence of monensin, the sodium salts of pyruvate, lactate, acetoacetate and β-hydroxybutyrate permeate in increasing order of effectiveness through liposomal membrans. This permeation is strongly pH dependent.Sodium pyruvate included in liposomes can be liberated into the medium by adding either monensin or other monocarboxylates. The latter process is a demonstration of an exchange diffusion of two compounds across a membrane without the help of a transport protein.