Assessing the association between self-report items for HIV pill adherence and biological measures
Assessing the association between self-report items for HIV pill adherence and biological measures
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DOI：
10.1080/09540121.2012.687816
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发表时间：
2012-01-01
影响因子：
1.7
通讯作者：
Nel, Adriaan
中科院分区：
文献类型：
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作者：
Kagee, Ashraf;Nel, Adriaan
在艾滋病毒感染者中坚持抗逆转录病毒治疗的次优药物可能会产生严重后果，包括健康状况下降，最终导致死亡。我们开发了一种工具来评估在南非一家公共卫生诊所就诊的患者中自我报告的药物对抗逆转录病毒治疗(ART)的依从性。该仪器基于之前发表的指南，包括五个问题和一个评估药物依从性行为的视觉模拟量表，并对101名艾滋病毒携带者进行了测试，他们在数据收集至少六个月前开始抗逆转录病毒治疗。量表的内部一致性一般，但不是很好(阿尔法信度=0.63)。参与者报告的避孕药依从性普遍较高。量表上的一个问题能够区分可检测到的病毒载量和低于可检测到的病毒载量(p<；0.01)。然而，合并后的项目并不能预测生物测量的依从性。尽管项目具有很好的理解性，但这项研究可能容易受到回忆和社会期望偏差的影响，而且只在诊所就诊者中进行，而不是那些就诊次数不同的人，这可能需要进一步研究。
Sub-optimal pill adherence to antiretroviral treatment among HIV-infected persons may have serious consequences, including a decline in health status, eventually leading to death. We developed an instrument to assess self-reported pill adherence to antiretroviral therapy (ART) among patients attending a public health clinic in South Africa. The instrument, based on previously published guidelines, consisted of five questions and a visual analogue scale assessing pill adherence behaviour and was administered to 101 patients living with HIV who commenced ART at least six months prior to data collection. The scale showed fair but not excellent internal consistency (alpha reliability = 0.63). Participants reported generally high levels of pill adherence. One question on the scale was able to distinguish between a detectable and a lower than detectable viral load (p < 0.01). Yet, the combined items did not predict biologically measured adherence. Despite good comprehensibility of items, the study may have been vulnerable to recall and social desirability bias and was conducted only among clinic attenders rather than those with varied levels of clinic attendance, which is potentially a matter for further study.