A Fully Automated Approach to Spike Sorting.
A Fully Automated Approach to Spike Sorting.
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DOI:
10.1016/j.neuron.2017.08.030
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发表时间:
2017-09-13
期刊:
影响因子:
16.2
通讯作者:
Greengard LF
中科院分区:
文献类型:
--
作者:
Chung JE;Magland JF;Barnett AH;Tolosa VM;Tooker AC;Lee KY;Shah KG;Felix SH;Frank LM;Greengard LF
Understanding the detailed dynamics of neuronal networks will require the simultaneous measurement of spike trains from hundreds of neurons (or more). Currently, approaches to extracting spike times and labels from raw data are time consuming, lack standardization and involve manual intervention, making it difficult to maintain data provenance and assess the quality of scientific results. Here, we describe an automated clustering approach and associated software package that addresses these problems and provides novel cluster quality metrics. We show that our approach has accuracy comparable to or exceeding that achieved using manual or semi-manual techniques with desktop CPU runtimes faster than acquisition time for up to hundreds of electrodes. Moreover, a single choice of parameters in the algorithm is effective for a variety of electrode geometries and across multiple brain regions. This algorithm has the potential to enable reproducible and automated spike sorting of larger scale recordings than is currently possible. Magland et. al. present MountainSort, a new fully automatic spike sorting package with a powerful GUI. MountainSort has accuracy comparable to current methods and runtimes faster than real-time, enabling automatic and reproducible spike sorting for high-density extracellular recordings.
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