Mapping grey matter reductions in schizophrenia: An anatomical likelihood estimation analysis of voxel-based morphometry studies
Mapping grey matter reductions in schizophrenia: An anatomical likelihood estimation analysis of voxel-based morphometry studies
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DOI：
10.1016/j.schres.2008.12.011
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发表时间：
2009-03-01
影响因子：
4.5
通讯作者：
Pantelis, C.
中科院分区：
文献类型：
--
作者：
Fornito, A.;Yuecel, M.;Pantelis, C.
基于体素的形态测量（VBM）是绘制精神分裂症患者神经解剖学变化的流行工具。最近的几项荟萃分析已经确定了患者最一致地表现出灰质减少的大脑区域，尽管他们没有检查这种变化是否反映了灰质浓度（GMC）或灰质体积（GMV）的差异。这些措施评估灰质完整性的不同方面，因此可能反映不同的病理过程。在这项研究中，我们使用解剖似然估计程序分析了 37 项精神分裂症患者 VBM 研究中报告的显着差异，纳入了 1646 名患者和 1690 名对照者的数据，并比较了使用 GMC 或 GMV 来索引灰质差异的研究结果。对所有研究的综合分析表明，额叶、颞叶、丘脑和纹状体区域网络中的灰质减少是文献中最常报道的。 GMC 的减少通常比 GMV 的减少幅度更大、更一致，并且在岛叶、内侧前额叶、内侧颞叶和纹状体区域更常见。 GMV 减少在背内侧额叶皮层、外侧和眼眶额叶区域更为常见。这些发现支持额叶、边缘和皮质下功能障碍在精神分裂症病理生理学中的首要地位，并表明 MRI 观察到的灰质变化可能不一定是单一病理过程的结果。 (C) 2008 Elsevier B.V. 保留所有权利。
Voxel-based morphometry (VBM) is a popular tool for mapping neuroanatomical changes in schizophrenia patients. Several recent meta-analyses have identified the brain regions in which patients most consistently show grey matter reductions, although they have not examined whether such changes reflect differences in grey matter concentration (GMC) or grey matter volume (GMV). These measures assess different aspects of grey matter integrity, and may therefore reflect different pathological processes. In this study, we used the Anatomical Likelihood Estimation procedure to analyse significant differences reported in 37 VBM studies of schizophrenia patients, incorporating data from 1646 patients and 1690 controls, and compared the findings of studies using either GMC or GMV to index grey matter differences. Analysis of all studies combined indicated that grey matter reductions in a network of frontal, temporal, thalamic and striatal regions are among the most frequently reported in literature. GMC reductions were generally larger and more consistent than GMV reductions, and were more frequent in the insula, medial prefrontal, medial temporal and striatal regions. GMV reductions were more frequent in dorso-medial frontal cortex, and lateral and orbital frontal areas. These findings support the primacy of frontal, limbic, and subcortical dysfunction in the pathophysiology of schizophrenia, and suggest that the grey matter changes observed with MRI may not necessarily result from a unitary pathological process. (C) 2008 Elsevier B.V. All rights reserved.