Outcome of medical and surgical therapy of GERD: Predictive role of quality of life scores and instrumental evaluation
Outcome of medical and surgical therapy of GERD: Predictive role of quality of life scores and instrumental evaluation
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DOI：
10.1016/j.ijsu.2014.05.034
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发表时间：
2014-08-01
影响因子：
15.3
通讯作者：
Fei, Landino
中科院分区：
文献类型：
--
作者：
Rossetti, Gianluca;Limongelli, Paolo;Fei, Landino
简介：本研究的目的是确定是否生活质量（QoL）评估与仪器评估可以帮助确定因素的预测结果在手术和药物治疗的胃食管反流病patients.Methods：2005年1月至2010年6月，301例受影响的胃食管反流病被列入研究。在治疗前、6个月、1年随访和研究结束时，通过GERD-HRQL和SF-36问卷评价QoL。采用多因素分析，观察性别、年龄、烧心、反酸、吞咽困难、食管炎、pH < 4的总时间百分比、症状指数评分（SI）、SF-36和HRQL评分等变量对研究结束时生活质量问卷评分的影响。147名患者被纳入手术组，154名患者被纳入药物组。治疗前性别、年龄、平均SF-36和HRQL评分无差异。研究结束时，无论是手术组还是内科组，SF-36和HRQL评分的生活质量均显著改善。多变量分析显示，没有单独影响SF-36和HRQL评分的因素，但症状指数评分（SI）和生活质量问卷评分在6个月和1年follow-up.Conclusions：结合使用pH测量与SI和生活质量问卷评价可以预测胃食管反流病患者的结果管理无论是通过内科或外科治疗。(C)2014 Surgical Associates Ltd.由Elsevier Ltd.发布。保留所有权利。
Introduction: Aim of this study is to determine whether quality of life (QoL) assessment in association with instrumental evaluation can help to identify factors predictive of outcome both in surgically and medically treated GERD patients.Methods: Between January 2005 and June 2010, 301 patients affected with GERD were included in the study. QoL was evaluated by means of GERD-HRQL and SF-36 questionnaires administered before treatment, at 6 months, at 1 year follow-up and at the end of the study. The multivariate analysis was used to detect if variables such as sex, age, heartburn, acid regurgitation, dysphagia, presence of esophagitis, percentage of total time at pH < 4, symptom index score (SI), the SF-36 and HRQL scores before treatment, at 6 months and 1 year could affect the QoL questionnaires scores at the end of the study.Results: One hundred forty-seven patients were included in the surgical group and 154 in the medical group. No differences with regard to gender, age, mean SF-36 and HRQL scores before treatment were documented. At the end of the study, quality of life was significantly improved for SF-36 and HRQL scores, either for surgical or medical group. The multivariate analysis showed no factors individually affected the SF-36 and the HRQL scores, but symptom index score (SI) and QoL questionnaires scores at 6 months and 1 year follow-up.Conclusions: The combined use of pHmetry with evaluation of SI and QoL questionnaires can predict the outcome of GERD patients managed either by medical or surgical therapy. (C) 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.