AMPHETAMINE AND APOMORPHINE RESPONSES IN RAT FOLLOWING 6-OHDA LESIONS OF NUCLEUS ACCUMBENS SEPTI AND CORPUS STRIATUM
AMPHETAMINE AND APOMORPHINE RESPONSES IN RAT FOLLOWING 6-OHDA LESIONS OF NUCLEUS ACCUMBENS SEPTI AND CORPUS STRIATUM
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DOI：
10.1016/0006-8993(75)90233-4
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发表时间：
1975-01-01
期刊：
影响因子：
2.9
通讯作者：
IVERSEN, SD
中科院分区：
文献类型：
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作者：
KELLY, PH;SEVIOUR, PW;IVERSEN, SD
大鼠双侧伏隔核或尾状核注射8μg 6-羟基多巴胺后，内源性多巴胺分别减少79%和50%。注射14天后，小剂量的苯丙胺未能在NAS损伤的大鼠中诱导出典型的运动反应，但在尾状核损伤的动物中产生了这种反应。相比之下，尾状核损害，而不是NAS损害，消除了由更高剂量的苯丙胺诱导的强烈形式的刻板印象行为。两组都表现出对多巴胺激动剂阿朴吗啡的超敏；NAS组表现出增强的运动活动，尾状核组表现出增强的刻板印象行为。安非他明运动阻滞和对阿朴吗啡的增强反应在术后14d左右最大，至90d时逐渐减弱。有证据表明，NAS中剩余的DA水平在术后90天高于14天。因此，行为效应的恢复与国家行动中剩余的多巴胺水平的增加有关。
Eight μg of 6-hydroxydopamine (6-OHDA) injected bilaterally into the nucleus accumbens septi (NAS) or the caudate nucleus of the rat resulted in 79% and 50% depletion of endogenous dopamine (DA) at these respective sites. Fourteen days after the injection a low dose of amphetamine failed to induce the characteristic locomotor response in the NAS-lesioned rats but did so in the caudate-lesioned animals. By contrast the caudate lesion, but not the NAS lesion, abolished intense forms of stereotyped behaviour induced by higher doses of amphetamine. Both lesioned groups exhibited supersensitivity to the dopamine agonist, apomorphine; the NAS group showed enhanced locomotor activity and the caudate group enhanced stereotyped behaviour. The block of amphetamine locomotion and the enhanced response to apomorphine were maximal around 14 days after the operation and gradually attenuated up to 90 days. There is evidence that remaining DA levels in the NAS are greater at 90 than at 14 days postoperatively. Thus recovery of behavioural effects correlated with an increase in the remaining levels of DA in the NAS.