Drug Insight: autoimmune effects of medications—what's new?
Drug Insight: autoimmune effects of medications—what's new?
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DOI：
10.1038/ncprheum0708
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发表时间：
2008-03
期刊：
影响因子：
--
通讯作者：
A. Mongey;E. Hess
中科院分区：
文献类型：
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作者：
A. Mongey;E. Hess
使用某些药物后可能会出现自身抗体和狼疮样综合征；然而，尽管许多患者产生自身抗体，但只有少数患者出现临床特征。尽管这些自身抗体主要由抗核和抗组蛋白抗体组成，但据报道其他类型的抗体，例如抗中性粒细胞胞浆抗体和抗双链 DNA 抗体与米诺环素和肿瘤坏死因子抑制剂治疗相关。药物相关性狼疮的临床特征通常包括全身症状、关节痛、关节炎、肌痛和浆膜炎，尽管已报道皮肤表现与肿瘤坏死因子抑制剂的使用有关。通常，临床特征会随着停药而消失，尽管抗体可能会持续数月或数年。据报道，关节痛和炎症性关节炎与芳香酶抑制剂和其他生物制剂（例如白细胞介素和干扰素）的使用有关。
Autoantibodies and lupus-like syndromes can develop following the use of certain medications; however, although many patients develop autoantibodies, only a minority develop clinical features. Although these autoantibodies primarily consist of antinuclear and antihistone antibodies, additional types of antibody, such as antineutrophil cytoplasmic antibodies and anti-double-stranded DNA antibodies, have been reported in association with minocycline and tumor necrosis factor inhibitor therapy. Clinical features of drug-related lupus usually consist of constitutional symptoms, arthralgias, arthritis, myalgias and serositis, although cutaneous manifestations have been reported in association with the use of tumor necrosis factor inhibitors. Typically, clinical features resolve with discontinuation of the medication, although antibodies can persist for months or years. Arthralgias and inflammatory arthritis have also been reported in association with the use of aromatase inhibitors and other biologic agents such as interleukins and interferons.