Deep gray matter perfusion in multiple sclerosis - Dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T
Deep gray matter perfusion in multiple sclerosis - Dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T
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DOI：
10.1001/archneur.64.2.196
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发表时间：
2007-02-01
影响因子：
--
通讯作者：
Grossman, Robert I.
中科院分区：
文献类型：
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作者：
Inglese, Matilde;Park, Sun-Jung;Grossman, Robert I.
目的：评估复发缓解型和原发性进展型多发性硬化症（MS）患者与健康对照组相比深部灰质灌注异常的存在，并研究灌注损伤对临床残疾和疲劳的影响。设计：调查。设置：研究型医院。患者：22名MS患者和11名年龄和性别匹配的健康志愿者。干预：测量丘脑、壳核和尾状核的绝对脑血流量、脑血容量和平均通过时间。主要结果测量：MS患者深部灰质脑血流量的减少以及灌注损伤与疲劳严重程度之间的相关性。原发进展型MS患者丘脑、壳核和尾状核的平均脑血流值显著降低（P
Objectives: To assess the presence of perfusion abnormalities in the deep gray matter of patients with relapsing-remitting and primary progressive multiple sclerosis ( MS) in comparison with healthy controls and to investigate the impact of perfusion impairment on clinical disability and fatigue.Design: Survey.Setting: Research-oriented hospital.Patients: Twenty-two patients with MS and 11 age- and sex-matched healthy volunteers.Intervention: Absolute cerebral blood flow, cerebral blood volume, and mean transit time were measured in the thalamus, putamen, and caudate nuclei.Main Outcome Measures: Decrease of cerebral blood flow in the deep gray matter of patients with MS and correlation between perfusion impairment and the severity of fatigue.Results: The cerebral blood flow value averaged over the thalamus, putamen, and caudate nuclei was significantly lower in patients with primary progressive MS (P