Bloom's syndrome .20. The first 100 cancers
Bloom's syndrome .20. The first 100 cancers
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DOI：
10.1016/s0165-4608(96)00336-6
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发表时间：
1997-01-01
影响因子：
--
通讯作者：
German, J
中科院分区：
文献类型：
--
作者：
German, J
截至1996年，第100例癌症被诊断为布卢姆综合征。自1960年以来，这些癌症一直被定期记录在一个被称为布卢姆综合征登记处的监测项目中。以下是他们的类型和发病年龄。在168名登记的个人中，有71人患上了100种癌症。布鲁姆综合征的代表是通常影响普通人群的癌症和儿童早期的罕见肿瘤。这些信息已经变得足够大，可以帮助遗传学家和医生向受影响的家庭提供有关癌症风险的建议。然而，具有更普遍意义的是，癌症部位和类型的分布将布卢姆综合征与其他癌症易感基因决定的条件区分开来，肯定了其作为分析人类癌症普遍性病因学中非环境成分的模型的实验价值。(C)Elsevier Science Inc.，1997.
As of 1996 the 100th cancer was diagnosed in Bloom's syndrome. The cancers have been regularly documented since 1960 in a program of surveillance referred to as the Bloom's Syndrome Registry. Tabulated here are their types and ages of onset. The 100 cancers arose in 71 of the 168 registered individuals. Represented in Bloom's syndrome are both the cancers that commonly affect the general population and the rare tumors of early childhood. This body of information has become sufficiently large to be useful to geneticists and physicians in advising affected families concerning cancer risk. Of more general significance, however, the distribution of cancer sites and types sets Bloom's syndrome apart from other cancer-predisposing genetically determined conditions, affirming its experimental value as a model for analyzing the nonenvironmental component in the etiology of the generality of human cancer. (C) Elsevier Science Inc., 1997.