Alterations of GABA and glutamate-glutamine levels in premenstrual dysphoric disorder: A 3T proton magnetic resonance spectroscopy study
Alterations of GABA and glutamate-glutamine levels in premenstrual dysphoric disorder: A 3T proton magnetic resonance spectroscopy study
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经前焦虑症中 GABA 和谷氨酸-谷氨酰胺水平的变化：3T 质子磁共振波谱研究
DOI：
10.1016/j.pscychresns.2014.10.020
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发表时间：
2015-01-30
影响因子：
2.3
通讯作者：
Rae, Caroline D.
中科院分区：
文献类型：
--
作者：
Liu, Bo;Wang, Guangbin;Rae, Caroline D.
越来越多的证据表明GABA能神经递质系统参与了经前焦虑症(PMDD)的发病。我们使用质子磁共振波谱(H-1MRS)来研究PMDD是否与大脑GABA水平的变化有关。同时检测谷氨酸-谷氨酰胺(GLX)水平。参与者包括22名PMDD妇女和22名年龄匹配的健康对照组，他们在月经周期的黄体晚期进行了3TH-1MRS检查。定量测定前扣带回皮质/内侧前额叶皮质(ACC/mPFC)和左侧基底节(ItBG)的GABA+和GLX水平。PMDD妇女ACC/mPFC和ItBG区的水标示GABA+浓度和GABA+/TCR比值均显著低于健康对照组。PMDD患者ACC/mPFC区GLX/TCR比值显著高于健康对照组。我们的初步发现首次报道了女性PMDD患者情绪相关脑区GABA+和GLX水平的异常，表明氨基酸神经递质系统的异常可能是PMDD发病的重要神经生物学机制。(C)2014爱思唯尔爱尔兰有限公司。保留所有权利。
Increasing evidence has suggested that the GABAergic neurotransmitter system is involved in the pathogenesis of premenstrual dysphoric disorder (PMDD). We used proton magnetic resonance spectroscopy (H-1 MRS) to investigate whether PMDD is associated with alterations in brain GABA levels. Levels of glutamate-glutamine (Glx) were also explored. Participants comprised 22 women with PMDD and 22 age-matched healthy controls who underwent 3 T H-1 MRS during the late luteal phase of the menstrual cycle. GABA + and Glx levels were quantified in the anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC) and the left basal ganglia (ItBG). Water-scaled GABA + concentrations and GABA +/tCr ratios were significantly lower in both the ACC/mPFC and ItBG regions of PMDD women than in healthy controls. Glx/tCr ratios were significantly higher in the ACC/mPFC region of PMDD women than healthy controls. Our preliminary findings provide the first report of abnormal levels of GABA + and Glx in mood-related brain regions of women with PMDD, indicating that dysregulation of the amino acid neurotransmitter system may be an important neurobiological mechanism in the pathogenesis of PMDD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.