Risk factors for glial cell proliferation after idiopathic macular hole repair with internal limiting membrane flap
Risk factors for glial cell proliferation after idiopathic macular hole repair with internal limiting membrane flap
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DOI：
10.1186/s12886-019-1265-0
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发表时间：
2019-12-21
影响因子：
2
通讯作者：
Chu, Yanhua
中科院分区：
文献类型：
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作者：
Liu, Yuyan;Wu, Changlong;Chu, Yanhua
目的探讨特发性黄斑裂孔（IMH）患者玻璃体切除术后内界膜（ILM）瓣技术不同愈合方式的影响因素。方法本研究为回顾性、连续性、观察性病例系列研究。我们招募了52名IMH患者，他们采用ILM皮瓣技术进行玻璃体切除术。参与者被分为2组：A组（25例患者），术后光学相干断层扫描（OCT）显示黄斑区无明显胶质细胞增殖; B组（27例患者），有明显胶质细胞增殖。比较两组患者术后视力（VA）、眼外界膜（ELM）和眼椭圆带（EZ）恢复情况。结果两组黄斑裂孔最小线径（MLD）和术后视力差异有统计学意义（p = 0.02，2.81 E-4）。与A组相比，B组患者术后前12个月VA和EZ恢复较差，ELM恢复时间较长。OCT结果显示，B组患者术后黄斑区ILM填充较A组患者更广泛。结论IMH的MLD较大与胶质细胞异常增殖有关，手术中ILM的填充方式与术后愈合方式和视力有关。
Background To study the influencing factors for different healing patterns of patients with idiopathic macular holes (IMH) after vitrectomy surgery performed with the internal limiting membrane (ILM) flap technique. Methods This study was a retrospective, consecutive, observational case series study. We recruited 52 IMH patients who underwent vitrectomy with the ILM flap technique. The participants were divided into 2 groups: group A (25 patients), without significant glial cell proliferation in the macular area on postoperative optical coherence tomography (OCT); and group B (27 patients), with significant glial cell proliferation. The postoperative visual acuity (VA), external limiting membrane (ELM) and ellipsoid zone (EZ) recovery characteristics were compared between the two groups. Results There were statistically significant differences in minimum linear diameter (MLD) of the macular hole and postoperative VA (p = 0.02, 2.81 E-4 respectively) between the two groups. Compared with patients in group A, patients in group B had poorer VA and EZ recovery in the first 12 months after surgery, and a longer ELM recovery period. The OCT results showed that patients in group B had more extensive ILM filling in the macular area after surgery than patients in group A. Conclusion The presence of aberrant glial cell proliferation was related to a larger MLD of the IMH, and the filling approach for the ILM during the operation was related to the postoperative healing pattern and vision acuity.