CHROMOSOME-BASED METHOD FOR RAPID COMPUTER-SIMULATION IN HUMAN GENETIC-LINKAGE ANALYSIS
CHROMOSOME-BASED METHOD FOR RAPID COMPUTER-SIMULATION IN HUMAN GENETIC-LINKAGE ANALYSIS
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DOI：
10.1002/gepi.1370100402
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发表时间：
1993-01-01
影响因子：
2.1
通讯作者：
OTT, J
中科院分区：
文献类型：
--
作者：
TERWILLIGER, JD;SPEER, M;OTT, J
计算机模拟一直是人体连锁分析的重要手段。通常，这样的分析已经通过根据标记间重组级分模拟一组连锁标记来进行，假设没有遗传干扰。提出了一种新的方法，其中这样的模拟可以使用基于染色体的方法，而不是传统的重组分数为基础的方法。我们建议使用交叉形成（CF）过程来模拟系谱数据，以产生交叉的数量和它们在摩根沿着整个染色体长度的位置。通过这种方法，可以生成模拟的多位点数据的染色体上的任何数量的基因座比目前可用的方法，如在SLINK或SIMLINK程序中使用的更有效。此外，干扰可以直接并入该方法中，这对于现有的封装是不可能的。(C)1993 Wiley-Liss，Inc.
Computer-based simulation has been an important method in human linkage analysis for a long time. Typically, such analyses have been performed by simulating a set of linked markers according to the intermarker recombination fractions, under the assumption of no genetic interference. A novel approach is proposed in which such simulations can be performed using chromosome-based methods, rather than traditional recombination fraction-based methods. We propose simulating pedigree data using a crossover formation (CF) process to generate the number of crossovers and their locations in Morgans along the entire length of a chromosome. By this method, one can generate simulated multilocus data for any number of loci on a chromosome much more efficiently than with the currently available methods like those used in the SLINK or SIMLINK programs. Further, interference can be incorporated directly in this method, which is not possible with existing packages. (C) 1993 Wiley-Liss, Inc.