Memory reconsolidation and extinction in the crab: Mutual exclusion or coexistence?
Memory reconsolidation and extinction in the crab: Mutual exclusion or coexistence?
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DOI：
10.1101/lm.1544609
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发表时间：
2009-11-01
影响因子：
2
通讯作者：
Maldonado, Hector
中科院分区：
文献类型：
--
作者：
Maria Perez-Cuesta, Luis;Maldonado, Hector
条件性刺激可以引起两种不同的记忆过程：记忆再巩固和记忆消退。我们实验室以前的工作表明，在单一的CS呈现时，一个或另一个过程的触发取决于CS的持续时间(短的CS暴露触发再巩固，而长的CS暴露触发消退)，两者是相互排斥的过程。在这里，我们表明，只有在CS偏移之后才会触发这两个过程，排除了作为这种互斥机制的相互作用。此外，我们在这里首次表明，如果再巩固和灭绝是由各自的短期和长期CS暴露连续触发的，那么它们可以同时发生，而不会相互干扰。因此，我们得出结论：(1)一个单一的CS呈现在CS偏移后触发了一个单一的过程；(2)记忆的再巩固和消退是相互排斥的，还是同时存在的，仅取决于它们是由单个CS呈现还是由多个CS呈现触发的。
A conditioned stimulus (CS) exposure has the ability to induce two qualitatively different mnesic processes: memory reconsolidation and memory extinction. Previous work from our laboratory has shown that upon a single CS presentation the triggering of one or the other process depends on CS duration (short CS exposure triggers reconsolidation, whereas a long CS exposure triggers extinction), both being mutually exclusive processes. Here we show that either process is triggered only after CS offset, ruling out an interaction as the mechanism of this mutual exclusion. Also, we show here for the first time that reconsolidation and extinction can occur simultaneously without interfering with each other if they are serially triggered by respective short and long CS exposures. Thus, we conclude that (1) one single CS presentation triggers one single process, after CS offset, and (2) whether memory reconsolidation and extinction mutually exclude each other or whether they coexist depends only on whether they are triggered by single or multiple CS presentations.