Matrix-producing Carcinoma: A Rare Variant of Metaplastic Breast Carcinoma with Heterologous Elements
Matrix-producing Carcinoma: A Rare Variant of Metaplastic Breast Carcinoma with Heterologous Elements
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DOI：
10.1111/j.1524-4741.2010.00925.x
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发表时间：
2010-07-01
期刊：
影响因子：
2.1
通讯作者：
Carter, Elliot
中科院分区：
文献类型：
--
作者：
Ayar, Sonali;Dyess, Donna Lynn;Carter, Elliot
乳腺基质生成癌(MPC)是一种罕见的变异型恶性肿瘤，被归类为含有异源成分的化生性乳腺癌。诊断MPC的主要标准是浸润性乳腺癌的存在，其直接转化为软骨或骨基质，没有中间的梭形细胞成分。MPC的细胞起源尚不清楚。有研究表明，MPC中的肿瘤细胞具有上皮和间质相结合的特征。一些报道认为肿瘤细胞起源于肌上皮细胞。MPC患者的预后最初被描述为类似于同一阶段的非特殊类型浸润性乳腺癌(NST)，但最近的一项研究表明，预后比同期NST更差。
Matrix-producing carcinoma (MPC) of the breast is a rare variant of the uncommon group of malignancies categorized as metaplastic breast carcinomas with heterologous elements. The major criterion for a diagnosis of MPC is the presence of invasive breast carcinoma with the direct transition to a cartilaginous or osseous stromal matrix without an intervening spindle cell component. The cellular origin of MPC remains unclear. It has been suggested that tumor cells in MPC have combined epithelial and mesenchymal features. Several reports have suggested that the tumor cells originate from myoepithelial cells. The prognosis of patients with MPC was originally described as similar to invasive mammary carcinomas of no special type (NST) of the same stage, but a more recent study has shown a worse prognosis than same-stage NSTs.