Hypothalamus volume in twin pairs discordant for schizophrenia
Hypothalamus volume in twin pairs discordant for schizophrenia
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DOI：
10.1016/j.euroneuro.2007.12.004
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发表时间：
2008-04-01
影响因子：
5.6
通讯作者：
Kahn, Rene S.
中科院分区：
文献类型：
--
作者：
M. P. Koolschijn, P. Cedric;M. van Haren, Neeltje E.;Kahn, Rene S.
将精神分裂症不一致的同卵双胞胎和同性异卵双胞胎与配对对照双胞胎进行比较，以解开遗传和环境对下丘脑体积变化的贡献。与健康对照组相比，在患者或不协调双胞胎中发现下丘脑体积减少，这可能归因于总脑体积减少。较高的同卵双胞胎对内的相似性相比，异卵双胞胎对，表明下丘脑体积可能是部分遗传控制。(c)2007年Elsevier B.V.和ECNP。All rights reserved.
Monozygotic and same-sex dizygotic twin pairs discordant for schizophrenia were compared with matched control twin pairs in order to disentangle genetic and environmental contributions to variation in hypothalamus volume. A decrease in hypothalamus volume was found in patients or discordant twin pairs compared to healthy controls which could be attributed to the decrease in total brain volume. Higher within-twin pair similarities in monozygotic compared to dizygotic twin pairs, suggests that hypothalamus volume might be partly genetically controlled. (c) 2007 Elsevier B.V. and ECNP. All rights reserved.