Cortisol responses to psychological stress in adults after prenatal exposure to the Dutch famine
Cortisol responses to psychological stress in adults after prenatal exposure to the Dutch famine
复制标题
DOI：
10.1016/j.psyneuen.2006.09.007
复制
发表时间：
2006-11-01
影响因子：
3.7
通讯作者：
Roseboom, Tessa J.
中科院分区：
文献类型：
--
作者：
de Rooij, Susanne R.;Painter, Rebecca C.;Roseboom, Tessa J.
动物实验研究表明，产前营养不良导致下丘脑-垂体-肾上腺（HPA）轴活动的终身改变。一些研究表明，低出生体重和HPA对心理压力的反应增加之间存在关联。我们测试的假设，产前暴露于荷兰1944-1945年的饥荒导致一个升高HPA反应的心理压力，在成年后的生活中，我们测量了唾液皮质醇反应的心理压力协议之间的694名成年人谁出生的足月独生子女在阿姆斯特丹，荷兰，在1944-1945年的荷兰饥荒的时间。我们比较了妊娠晚期（n = 120）、中期（n = 100）或早期（n = 62）暴露于饥饿的参与者与妊娠期未暴露于饥饿的参与者（n = 412）的皮质醇浓度，皮质醇浓度较基线平均增加30%（95%CI 23-37）。有没有统计学上的显着差异，平均配置皮质醇反应的心理应激协议之间的参与者暴露和未暴露于饥饿在子宫内。暴露者与未暴露者相比，皮质醇反应的平均性别和BMI调整差异为-6%（95% CI：-15至2）。那些暴露在晚些时候，（-4% [95% CI：-16至7]），中等（-9% [95% CI：-22至3]）或妊娠早期（-4% [95% Cl：-20至10]）我们的结论是，产前暴露于饥饿似乎并不与HPA轴的反应，心理压力然而，我们使用的应激方案可能未能成功诱导足够强的HPA轴激活，从而能够检测到饥饿相关的差异。(c)2006爱思唯尔有限公司版权所有。
Experimental studies in animals show that prenatal undernutrition leads to lifelong alterations in the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Some studies have shown associations between low birth weight and an increased HPA response to psychological stress. We tested the hypothesis that prenatal exposure to the Dutch 1944-1945 famine leads to an elevated HPA response to psychological stress in adult life.We measured salivary cortisol responses to a psychological stress protocol among 694 adults who were born as term singletons in Amsterdam, the Netherlands, around the time of the 1944-1945 Dutch famine. We compared cortisol profiles of participants exposed to famine during late (n = 120), mid (n = 100), or early gestation (n = 62) to profiles of participants unexposed to famine during gestation (n = 412).The mean increase in cortisol concentrations from baseline was 30% (95% Cl 23-37). There were no statistically significant differences in the mean profile of cortisol response to the psychological stress protocol between participants exposed and unexposed to famine in utero. The mean sex and BMI adjusted difference in cortisol response for those exposed compared to those unexposed was -6% (95% Cl: -15 to 2). The cortisol profiles of those exposed in late (-4% [95% Cl: -16 to 7]), mid (-9% [95% Cl: -22 to 3]) or early gestation (-4% [95% Cl: -20 to 10]) did not differ from the profile of those unexposed to famine.We conclude that prenatal exposure to famine does not seem to be associated with the response of the HPA axis to psychological stress. However, the stress protocol we have used may have been unsuccessful in inducing a strong enough HPA axis activation to be able to detect famine related differences. (c) 2006 Elsevier Ltd. All rights reserved.