Memory systems analyses of mnemonic disorders in aging and age-related diseases
Memory systems analyses of mnemonic disorders in aging and age-related diseases
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DOI：
10.1073/pnas.93.24.13534
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发表时间：
1996-11-26
影响因子：
11.1
通讯作者：
Gabrieli, JDE
中科院分区：
文献类型：
--
作者：
Gabrieli, JDE
正常衰老和两种与年龄相关的神经退行性疾病（阿尔茨海默病（AD）和帕金森病）对记忆的影响从记忆系统、介导特定记忆过程的特定神经网络、介导内隐视觉感知记忆的枕叶记忆系统似乎不受衰老或 AD 的影响进行分析。可能介导内隐概念记忆的额叶系统会受到 AD 的影响，但不会受到正常衰老的影响。调节工作和策略记忆方面的另一个额叶系统受到帕金森病的影响，并且在较小程度上受到衰老的影响。衰老效应似乎发生在成人寿命的所有年龄段。最后，调节陈述性记忆的内侧颞叶系统受到 AD 晚期发作的影响。对与年龄相关的疾病中完整记忆和受损记忆的研究表明，正常衰老对不同记忆系统有明显不同的影响。
The effects upon memory of normal aging and two age-related neurodegenerative diseases, Alzheimer disease (AD) and Parkinson disease, are analyzed in terms of memory systems, specific neural networks that mediate specific mnemonic processes, lin occipital memory system mediating implicit visual-perceptual memory appears to be unaffected by aging or AD. A frontal system that may mediate implicit conceptual memory is affected by AD but not by normal aging. Another frontal system that mediates aspects of working and strategic memory Is affected by Parkinson disease and, to a lesser extent, by aging, The aging effect appears to occur during all ages of the adult life-span. Finally, a medial-temporal system that mediates declarative memory is affected by the late onset of AD. Studies of intact and impaired memory in age-related diseases suggest that normal aging has markedly different effects upon different memory systems.