Principles and requirements for stroke recovery science.
Principles and requirements for stroke recovery science.
复制标题
中风康复学的原则和要求。
DOI：
10.1177/0271678x20970048
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Schäbitz WR
中科院分区：
文献类型：
--
作者：
Sommer CJ;Schäbitz WR
神经保护策略从实验到临床的转化结果令人失望，这导致中风研究向增强大脑内源性恢复潜力的方向发生了一定的转变。关注康复的一个原因是治疗干预的时间窗口要宽得多，至少有几个月的时间。由于最近两项分别使用d-安非他明或氟西汀来提高中风后神经预后的大型临床研究再次失败，这是对中风恢复科学的原则和要求进行批判性反思的好时机。原则上，脑卒中恢复科学涉及脑缺血后发生的从分子到功能和行为水平的所有事件，最终以各种临床参数的可测量改善而告终。对自发发生的缺血后再生过程的详细了解是任何旨在改变这些反应以增强中风后恢复的治疗方法不可或缺的先决条件。本文将简要阐述缺血后再生的分子机制和促进脑卒中后恢复的主要可能性。在此背景下，分析了最近的翻译方法。最后，将讨论脑卒中恢复研究的主要和具体要求、缺陷以及翻译失败的潜在解释。
The disappointing results in bench-to-bedside translation of neuroprotective strategies caused a certain shift in stroke research towards enhancing the endogenous recovery potential of the brain. One reason for this focus on recovery is the much wider time window for therapeutic interventions which is open for at least several months. Since recently two large clinical studies using d-amphetamine or fluoxetine, respectively, to enhance post-stroke neurological outcome failed again it is a good time for a critical reflection on principles and requirements for stroke recovery science. In principal, stroke recovery science deals with all events from the molecular up to the functional and behavioral level occurring after brain ischemia eventually ending up with any measurable improvement of various clinical parameters. A detailed knowledge of the spontaneously occurring post-ischemic regeneration processes is the indispensable prerequisite for any therapeutic approaches aiming to modify these responses to enhance post-stroke recovery. This review will briefly illuminate the molecular mechanisms of post-ischemic regeneration and the principle possibilities to foster post-stroke recovery. In this context, recent translational approaches are analyzed. Finally, the principal and specific requirements and pitfalls in stroke recovery research as well as potential explanations for translational failures will be discussed.
影响因子：
3.1
作者：
Wahl AS
通讯作者：
Wahl AS