Granulocyte-macrophage colony-stimulating factors
Granulocyte-macrophage colony-stimulating factors
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粒细胞-巨噬细胞集落刺激因子
DOI：
10.1007/978-3-642-73325-3_5
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
N. Gough
中科院分区：
文献类型：
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作者：
N. Gough
造血是一个过程，其中一小群多能干细胞不断产生大量的成熟血细胞，包括八个不同的细胞谱系。在正常的健康状态下，成熟细胞的循环水平是显著不变的，这表明它们的产生受到严格的调节。然而，造血系统也是灵活的，允许各种细胞类型的水平波动，以满足紧急情况，如失血，感染或氧张力降低。一些控制造血的机制，特别是与干细胞群体有关的机制，似乎涉及造血细胞与血细胞形成部位微环境中其他细胞之间的接触（例如，艾伦1981）。然而，在半固体培养系统中从单个祖细胞生长成熟造血细胞集落的能力也涉及许多可溶性糖蛋白生长因子。这些因子被称为集落刺激因子（CSF），已在体外显示可刺激不同造血谱系内细胞的增殖、分化和功能活化（Metcalf 1984）。
Haemopoiesis is the process whereby a small population of multipotential stem cells continuously gives rise to a large number of mature blood cells which comprise eight distinct cellular lineages. In normal health, the circulating levels of mature cells are remarkably invariant, suggesting that their production is tightly regulated. However, the haemopoietic system is also flexible, allowing fluctuations in the levels of various cell types to meet emergency situations such as blood loss, infection or reduced oxygen tension. Some of the mechanisms controlling haemopoiesis, particularly those concerned with stem cell populations, appear to involve contact between haemopoietic cells and other cells in the micro-environment at the sites of blood cell formation (e.g. Allen 1981). However, the ability to grow colonies of mature haemopoietic cells from single progenitor cells in semi-solid culture systems has also implicated a number of soluble glycoprotein growth factors. These factors, known as colony-stimulating factors (CSFs), have been shown in vitro to stimulate the proliferation, differentiation and functional activation of cells within different haemopoietic lineages (Metcalf 1984).
T 淋巴细胞克隆中粒细胞-巨噬细胞集落刺激因子和多谱系集落刺激因子产生的独立调节。
DOI：
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发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kelso,A;Metcalf,D;Gough,NM
通讯作者：
Gough,NM